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T-cell exhaustion in HIV infection
Journal article   Open access   Peer reviewed

T-cell exhaustion in HIV infection

Mohamed El-Far, Halwani Rabih, Said Elias, Trautmann Lydie, Doroudchi Mehrnoosh, Janbazian Loury, Simone Fonseca, van Julien, Yassine-Diab Bader, Sékaly Rafick-Pierre, …
Current HIV/AIDS reports, v 5(1), pp 13-19
01 Jan 2008
DOI: https://doi.org/10.1007/s11904-008-0003-7
PMID: 18417030
url
https://link.springer.com/content/pdf/10.1007/s11904-008-0003-7.pdfView
Published, Version of Record (VoR) Open
url
https://doi.org/10.1007/s11904-008-0003-7View
Published, Version of Record (VoR) Open

Abstract

CD4 antigen Hepatitis C HIV Human immunodeficiency virus Immunological memory Lymphocytes T Memory cells Molecular modelling
Generation of memory T cells, which mediate immunity against microbes and cancers, relies, for optimal activity, on the interactions of multiple cell types that are highly regulated through the expression of soluble factors and negative and positive receptors. Their disruption will lead to aberrant immune responses, which can result in the invasion of the host by foreign pathogens. In chronic viral infections including HIV and hepatitis C virus, persistence of antigen and lack of CD4 help (HIV) disrupt memory T-cell function and induce defects in memory T-cell responses, which have been defined as T-cell exhaustion. In this review, we examine the molecular mechanisms involved in such T-cell dysfunction. Better understanding of these mechanisms will assist in the development of novel therapies to prevent the immune damage mediated by HIV infection.

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