Journal article
T-kininogen: a biomarker of aging in Fisher 344 rats with possible implications for the immune response
The journals of gerontology. Series A, Biological sciences and medical sciences, v 61(7), pp 641-649
Jul 2006
PMID: 16870624
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
T-kininogen (T-KG) is a reliable biomarker of aging in male Sprague-Dawley rats. Here we confirm, in a longitudinal study, a similar behavior in Fisher 344 rats of both sexes. In males, the increase in serum levels of T-KG follows an exponential curve, whereas in females the increase is best fitted by a linear curve. In both genders, dietary restriction delays the increase in T-KG. We have previously shown that T-KG inhibits T lymphocyte proliferation. Here we show that serum T-KG levels correlate negatively with the ability of splenocytes (most likely B cells) to proliferate in response to lipopolysaccharide. A similar correlation was not observed with other markers of inflammation, including alpha1-acid glycoprotein (AGP), haptoglobin, or interleukin-10. We conclude that the increase in serum T-KG represents a useful biomarker of aging in Fisher 344, and it correlates with decreased lymphocyte proliferation with age, although a cause-effect relationship has not been established.
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Details
- Title
- T-kininogen: a biomarker of aging in Fisher 344 rats with possible implications for the immune response
- Creators
- Claudio Acuña-Castillo - Instituto de Ciencias Biomédicas, Progama de Biología Celular y Molecular, Facultad de Medina, Universidad de Chile, SantiagoElias Leiva-SalcedoChristian R GómezViviana PérezMin LiClaudio TorresRobin WalterDonna M MuraskoFelipe Sierra
- Publication Details
- The journals of gerontology. Series A, Biological sciences and medical sciences, v 61(7), pp 641-649
- Publisher
- Oxford University Press; United States
- Grant note
- R01 AG 7719 / NIA NIH HHS R01 AG 13902 / NIA NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology; Neurobiology and Anatomy
- Web of Science ID
- WOS:000239642600003
- Scopus ID
- 2-s2.0-33746589035
- Other Identifier
- 991014877655404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Geriatrics & Gerontology
- Gerontology