Journal article
THE EFFECT OF PATIENT-SPECIFIC NON-NEWTONIAN BLOOD VISCOSITY ON ARTERIAL HEMODYNAMICS PREDICTIONS
Journal of mechanics in medicine and biology, v 19(8), p1940054
01 Dec 2019
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Blood flow simulations can identify arterial regions that are vulnerable to atherosclerotic or thrombotic evolution. To accurately define vulnerable arterial regions, hemodynamic parameters such as arterial geometry, blood flow velocity and blood viscosity (BV) must be measured individually. However, previous numerical studies have largely employed either a single representative value or simply used a nonspecific curve of non-Newtonian characteristics of BV. This study aimed to evaluate whether various BV models could produce similar arterial wall shear stress (WSS) results. We performed a blood flow simulation in carotid arteries obtained from time-of-flight magnetic resonance (TOF MR) angiography using the hemodynamic characteristics of subjects via carotid duplex ultrasonography. The BV models were categorized into the following five types: patient-specific non-Newtonian BV (model 1), representative non-Newtonian BV based on the Carreau model (BV model 2), Newtonian BV measured at a specific shear rate of 300s(-1) (BV model 3), Newtonian BV obtained from a hematocrit-based equation (BV model 4) and a representative Newtonian BV of 4cP (BV model 5). In total, 20 carotid arteries from 20 healthy volunteers (mean age +/- SD of 63.5 +/- 8.1 years; 50% women) were examined. Compared with the mean values of carotid WSS in BV model 1 as the reference model, the other four models showed significant differences in both genders for all carotid segments. To obtain reliable physiological WSS results, patient-specific non-Newtonian BV should be carefully employed.
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Details
- Title
- THE EFFECT OF PATIENT-SPECIFIC NON-NEWTONIAN BLOOD VISCOSITY ON ARTERIAL HEMODYNAMICS PREDICTIONS
- Creators
- Sang Hyuk Lee - Korea Inst Machinery & Mat, Dept Nucl Equipment Safety, Daejeon, South KoreaKap-Soo Han - Jeonbuk National UniversityNahmkeon Hur - Department of Mechanical Engineering; Sogang University; Seoul Republic of KoreaYoung Cho - Drexel UniversitySeul-Ki Jeong - Jeonbuk National University
- Publication Details
- Journal of mechanics in medicine and biology, v 19(8), p1940054
- Publisher
- World Scientific
- Number of pages
- 15
- Grant note
- Biomedical Research Institute of Chonbuk National University Hospital NRF-2013R1A1A2011846 / National Research Foundation of Korea (NRF) - Ministry of Education Research Institute of Clinical Medicine, Chonbuk National University 20090083510 / National Research Foundation of Korea (NRF) - Korean government (MSIP)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000505683500009
- Scopus ID
- 2-s2.0-85076703405
- Other Identifier
- 991019203359904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biophysics
- Engineering, Biomedical