Journal article
THE GEOMETRICAL CHARACTERIZATION OF NEURAL ACTIVITY DISPLAYS A SENSITIVITY TO CONVULSANTS
International journal of bifurcation and chaos in applied sciences and engineering, v 1(1), pp 253-259
01 Mar 1991
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Direct application of a drop of penicillin to the brain's surface can elicit brain electrical activity similar to that seen in some forms of epilepsy. The procedure has therefore become one of the standard techniques in the experimental investigation of epilepsy. The time intervals between action potentials, called the interspike intervals, were measured from single nerve cells in the cerebral cortex of the rat before and after local administration of penicillin. The resulting interspike interval data were examined by elementary statistical procedures and by embedding the data in two- and three-dimensional spaces. The mean interspike interval did not change significantly in response to penicillin. In contrast, the geometrical characterization displayed a dramatic sensitivity to the drug.
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Details
- Title
- THE GEOMETRICAL CHARACTERIZATION OF NEURAL ACTIVITY DISPLAYS A SENSITIVITY TO CONVULSANTS
- Creators
- I. D. Zimmerman - Drexel UniversityP. E. Rapp - Drexel UniversityA. I. Mees - The University of Western Australia
- Publication Details
- International journal of bifurcation and chaos in applied sciences and engineering, v 1(1), pp 253-259
- Publisher
- World Scientific
- Number of pages
- 7
- Grant note
- Whitaker Foundation Allegheny Singer Foundation College Computer Center of the Medical College of Pennsylvania NS19716 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000209750300017
- Other Identifier
- 991019330618304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Mathematics, Interdisciplinary Applications