Journal article
TNAP, a Novel Repressor of NF- Kappa B-inducing Kinase, Suppresses NF- Kappa B Activation
The Journal of biological chemistry, v 279(34), pp 35975-35983
20 Aug 2004
PMID: 15208311
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
NF- Kappa B-inducing kinase (NIK) has been implicated as an essential component of NF- Kappa B activation. However, the regulatory mechanism of NIK signaling remains elusive. We have identified a novel NIK interacting protein, TNAP (for TRAFs and NIK-associated protein). In mammalian cells, TNAP physically interacts with NIK, TRAF2, and TRAF3 but not IKK1 or IKK2. TNAP specifically inhibits NF- Kappa B activation induced by tumor necrosis factor (TNF)-alpha, TNF receptor 1, TRADD, RIP, TRAF2, and NIK but does not affect IKK1- and IKK2- mediated NF- Kappa B activation. Knockdown of TNAP by lentiviral-mediated small interference RNA potentiates TNF-alpha-induced NF- Kappa B activation. TNAP suppresses NIK kinase activity and subsequently reduces p100 processing, p65 phosphorylation, and I Kappa Balpha degradation. These data suggest that TNAP is a repressor of NIK activity and regulates both the classical and alternative NF- Kappa B signaling pathways.
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Details
- Title
- TNAP, a Novel Repressor of NF- Kappa B-inducing Kinase, Suppresses NF- Kappa B Activation
- Creators
- Wen-Hui Hu - Miami Project to Cure ParalysisXian-Ming Mo - Max Delbrück CenterWinston Walters - Miami Project to Cure ParalysisRoberta Brambilla - Miami Project to Cure ParalysisJohn Bethea - University of Miami
- Publication Details
- The Journal of biological chemistry, v 279(34), pp 35975-35983
- Publisher
- ASBMB Publications / Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology; College of Arts and Sciences; Drexel University
- Web of Science ID
- WOS:000223303400099
- Scopus ID
- 2-s2.0-4143144401
- Other Identifier
- 991020100076304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology