Journal article
TRAIL in the airways
Vitamins and hormones, v 67, pp 149-167
2004
PMID: 15110176
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) is an important immunomodulatory factor that may play a role in the structural changes observed in the asthmatic airways. In vitro as well as in vivo studies have evidenced a dual role for TRAIL: it can either function as a pro- or anti-inflammatory cytokine on inflammatory cells, participating in the initiation and resolution of inflammatory and immune responses. TRAIL is expressed in the airways by inflammatory cells infiltrated in the bronchial mucosa, as well as by structural cells of the airway wall including fibroblasts, epithelial, endothelial, and smooth muscle cells. By releasing TRAIL, these different cell types may then participate in the increased levels of TRAIL observed in bronchoalveolar lavage fluid from asthmatic patients. Taken together, this suggests that TRAIL may play a role in inflammation in asthma. However, concerning its role is dual in the modulation of inflammation, further studies are needed to elucidate the precise role of TRAIL in the airways.
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Details
- Title
- TRAIL in the airways
- Creators
- Noreen M Robertson - Thomas Jefferson UniversityMary Rosemiller - Thomas Jefferson UniversityRochelle G Lindemeyer - University of PennsylvaniaAndrzej Steplewski - Thomas Jefferson UniversityJames G Zangrilli - Thomas Jefferson UniversityGerald Litwack
- Publication Details
- Vitamins and hormones, v 67, pp 149-167
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- SOM Dean - Research Administration
- Web of Science ID
- WOS:000285800500009
- Scopus ID
- 2-s2.0-3042784480
- Other Identifier
- 9780080522876; 0080522874; 991021448187004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Endocrinology & Metabolism
- Oncology