Journal article
TRANSACTIVE RESPONSE DNA-BINDING PROTEIN-43 PATHOLOGY IN ALZHEIMER'S DISEASE: COMBINED DISEASE OR SHARED DEGENERATIVE PATHWAYS?
Cognitive science (Hauppauge, N.Y.), Vol.6(1), p55
01 Jan 2011
Abstract
With recent discovery of transactive response DNA-binding protein-43 (TDP-43) as the major component of ubiquitinated inclusions seen in sporadic and familial forms of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) there is great interest in the role of this protein in neurodegenerative disease. TDP-43 is considered a new proteinopathy linking FTLD and ALS in clinicopathologic continuum. Since this discovery, the role of TDP-43 has been explored in other degenerative diseases. TDP-43 inclusions have been described in a subset of Alzheimer's disease (AD) patients, mostly found in the limbic structures (amygdala and hippocampus), and in some cases more diffusely in the frontal and temporal neocortex. These inclusions share biochemical and histologic features of the TDP-43 lesions seen in FTLD cases with ubiquitinated inclusions (FTLD-U). The clinical significance of these findings is unclear, with controversy over the co-existence of FTLD and AD in these patients. We will review the current data on TDP-43 pathology in AD and possible implications on diagnosis and development of disease modifying treatment in AD and FTLD.
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- Title
- TRANSACTIVE RESPONSE DNA-BINDING PROTEIN-43 PATHOLOGY IN ALZHEIMER'S DISEASE: COMBINED DISEASE OR SHARED DEGENERATIVE PATHWAYS?
- Creators
- D J IrwinC F Lippa
- Publication Details
- Cognitive science (Hauppauge, N.Y.), Vol.6(1), p55
- Publisher
- Nova Science Publishers, Inc
- Resource Type
- Journal article
- Language
- English
- Identifiers
- 991019312442804721