Journal article
TRANSFORMING GROWTH FACTOR- βS IN NEURODEGENERATIVE DISEASE
Progress in neurobiology, v 54(1)
1998
PMID: 9460794
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Transforming growth factors-
βs (TGF-
βs), a family of multifunctional peptide growth factors, affect cells of the central nervous system (CNS). The three mammalian TGF-
β isoforms, TGF-
βs 1, 2 and 3, are expressed in adult human brain. Since neuronal degeneration is a defining feature of CNS degenerative diseases, TGF-
β may be important because it can influence neuronal survival.
In vitro TGF-
β promotes survival of rat spinal cord motoneurons and dopaminergic neurons. In addition to direct effects on neuronal survival, TGF-
β treatment of cultured astrocytes induces a reactive phenotype. Thus, TGF-
β may also normalize the extracellular matrix environment in degenerative diseases. The expression of TGF-
βs change in response to neuronal injury. TGF-
β1 expression increases in astrocytes and microglia in animal models of cerebral ischemia, while TGF-
β2 expression increases in activated astroglial cells in human neurodegenerative diseases. TGF-
βs protect neurons from a variety of insults. TGF-
β maintains survival of chick telencephalic neurons made hypoxic by treatment with cyanide and decreases the area of infarction when administered in animal models of cerebral ischemia.
In vitro TGF-
β protects neurons from damage induced by treatment with
β-amyloid peptide, FeSO
4 (induces production of reactive oxygen species), Ca
2+ ionophores, glutamate, glutamate receptor agonists and MPTP (toxic for dopaminergic neurons). TGF-
β maintains mitochondrial potential and Ca
2+ homeostasis and inhibits apoptosis in neurons. TGF-
β does not prevent neuronal degeneration in a rat model of Parkinson's disease and has yet to be tested in newly developed transgenic mouse models of Alzheimer's disease. TGF-
β is a potent neuroprotective agent which may affect the pathogenesis of neurodegenerative diseases of the CNS.
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Details
- Title
- TRANSFORMING GROWTH FACTOR- βS IN NEURODEGENERATIVE DISEASE
- Creators
- KATHLEEN C Flanders - National Cancer InstituteRENEÉ F Ren - National Cancer InstituteCAROL F Lippa - Allegheny University of the Health Sciences
- Publication Details
- Progress in neurobiology, v 54(1)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000071370900005
- Scopus ID
- 2-s2.0-0031975391
- Other Identifier
- 991019312385704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences