Journal article
Tailoring the physicochemical properties of nanomaterials for immunomodulation
Advanced drug delivery reviews, v 180, 114039
Jan 2022
PMID: 34742825
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Nanomaterial physicochemical properties affect their immunomodulation. Here, size, surface charge, shape, rigidity and surface chemical composition of nanomaterials are discussed for understanding nanomaterials-induced immune responses.
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Immunomodulation is poised to revolutionize the treatment of cancer, autoimmune diseases, and many other inflammation-related disorders. The immune system in these conditions can be either activated or suppressed by nanocarriers loaded with bioactive molecules. Although immunomodulation via these therapeutics has long been recognized, and a broad range of nanocarriers have been designed to accommodate varied usages, less studies have focused on the effects of nanomaterial physicochemical properties on immune responses, especially the immunity altered by nanocarrier materials alone. Conclusions are sometimes seemly inconsistent due to the complexities of nanomaterials and the immune system. An in-depth understanding of the nanocarrier-induced immune responses is essential for clinical applications. In this review, we summarize recent studies of the immune responses influenced by nanomaterial physicochemical properties with an emphasis on the intrinsic features of nanomaterials that modulate the innate and adaptive immunities. We then provide our perspectives on the design of nanomaterials for immunomodulation.
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Details
- Title
- Tailoring the physicochemical properties of nanomaterials for immunomodulation
- Creators
- Junjie Deng - First Affiliated Hospital of Wenzhou Medical UniversityJilong Wang - First Affiliated Hospital of Wenzhou Medical UniversityJiaqi Shi - Zhejiang UniversityHongjun Li - College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; Zhejiang Laboratory of Systems and Precision Medicine, Zhejiang University Medical Center, Hangzhou 311121, China.Mingqin Lu - First Affiliated Hospital of Wenzhou Medical UniversityZhiyuan Fan - Drexel UniversityZhen Gu - Zhejiang Laboratory of Systems and Precision Medicine, Zhejiang University Medical Center, Hangzhou 311121, ChinaHao Cheng - Drexel University
- Publication Details
- Advanced drug delivery reviews, v 180, 114039
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Web of Science ID
- WOS:000723581900009
- Scopus ID
- 2-s2.0-85119526224
- Other Identifier
- 991019168375804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Pharmacology & Pharmacy