Files and links (2)
Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
Taking Advantage: High-Affinity B Cells in the Germinal Center Have Lower Death Rates, but Similar Rates of Division, Compared to Low-Affinity Cells
The Journal of immunology (1950), v 183(11), pp 7314-7325
01 Dec 2009
PMID: 19917681
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
B lymphocytes producing high-affinity Abs are critical for protection from extracellular pathogens, such as bacteria and parasites. The process by which high-affinity B cells are selected during the immune response has never been elucidated. Although it has been shown that high-affinity cells directly outcompete low-affinity cells in the germinal center (GC), whether there are also intrinsic differences between these cells has not been addressed. It could be that higher affinity cells proliferate more rapidly or are more likely to enter cell cycle, thereby outgrowing lower affinity cells. Alternatively, higher affinity cells could be relatively more resistant to cell death in the GC. By comparing high- and low-affinity B cells for the same Ag, we show here that low-affinity cells have an intrinsically higher death rate than do cells of higher affinity, even in the absence of competition. This suggests that selection in the GC reaction is due at least in part to the control of survival of higher affinity B cells and not by a proliferative advantage conferred upon these cells compared with lower affinity B cells. Control over survival rather than proliferation of low- and high-affinity B cells in the GC allows greater diversity not only in the primary response but also in the memory response. The Journal of Immunology, 2009, 183: 7314-7325.
Metrics
Details
- Title
- Taking Advantage: High-Affinity B Cells in the Germinal Center Have Lower Death Rates, but Similar Rates of Division, Compared to Low-Affinity Cells
- Creators
- Shannon M. Anderson - Yale UniversityAshraf Khalil - Yale Univ, Sch Med, Dept Lab Med, New Haven, CT 06520 USAMohamed Uduman - Yale Univ, Sch Med, Interdept Program Computat Biol & Bioinformat, New Haven, CT 06520 USAUri Hershberg - Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USAYoram Louzoun - Bar Ilan Univ, Dept Math, Ramat Gan, IsraelAnn M. Haberman - Yale Univ, Sch Med, Dept Lab Med, New Haven, CT 06520 USASteven H. Kleinstein - Yale Univ, Sch Med, Interdept Program Computat Biol & Bioinformat, New Haven, CT 06520 USAMark J. Shlomchik - Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
- Publication Details
- The Journal of immunology (1950), v 183(11), pp 7314-7325
- Publisher
- American Association of Immunologists
- Number of pages
- 12
- Grant note
- R01AI043603 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) DGE-9972930 / National Science Foundation; National Science Foundation (NSF) R01-AI43603 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000272478800052
- Scopus ID
- 2-s2.0-73349126428
- Other Identifier
- 991019280036804721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Immunology