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Tandemly arranged gene clusters of malarial parasites that are highly conserved and transcribed
Journal article   Peer reviewed

Tandemly arranged gene clusters of malarial parasites that are highly conserved and transcribed

Akhil B Vaidya and Prema Arasu
Molecular and biochemical parasitology, v 22(2), pp 249-257
1987
PMID: 3033497

Abstract

Plasmodium Repetitive DNA Evolution Gene organization Malaria Gene expression
A molecular clone containing a 5.8 kb Eco RI fragment was isolated from a genomic library of the rodent malarial parasite Plasmodium yoelii. The P. yoelii genome contains about 150 copies of this sequence, making up almost 3% of the DNA. These sequences are tandemly arrayed in head-to-tail configurations with the unit length of the repeat being 5.8 kb. Several poly(A +) RNAs of P. yoelii ranging from 1.6 to 0.3 kb are recognized by the 5.8 kb clone. Five additional species of malarial parasites ( P. chabaudi, P. berghei, P. falciparum, P. knowlesi, and P. cynomolgi) contain tandemly repeated arrays of sequences having the same unit length of 5.8 kb, which readily hybridize to the sequence cloned from P. yoelii.

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Web of Science research areas
Biochemistry & Molecular Biology
Parasitology
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