Journal article
Targeting beta-Cell Function Early in the Course of Therapy for Type 2 Diabetes Mellitus
The journal of clinical endocrinology and metabolism, v 95(9), pp 4206-4216
01 Sep 2010
PMID: 20739389
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective: This report examines current perspectives regarding likely mechanisms of beta-cell failure in type 2 diabetes and their clinical implications for protecting or sparing beta-cells early in the disease progression. In addition, it considers translation strategies to incorporate relevant scientific findings into educational initiatives targeting clinical practice behavior.
Participants: On January 10, 2009, a working group of basic researchers, clinical endocrinologists, and primary care physicians met to consider whether current knowledge regarding pancreatic beta-cell defects justifies retargeting and retiming treatment for clinical practice. Based on this meeting, a writing group comprised of four meeting participants subsequently prepared this consensus statement. The conference was convened by The Endocrine Society and funded by an unrestricted educational grant from Novo Nordisk.
Evidence: Participants reviewed and discussed published literature, plus their own unpublished data.
Consensus Process: The summary and recommendations were supported unanimously by the writing group as representing the consensus opinions of the working group.
Conclusions: Workshop participants strongly advocated developing new systems to address common barriers to glycemic control and recommended several initial steps toward this goal. These recommendations included further studies to establish the clinical value of pharmacological therapies, continuing basic research to elucidate the nature and mechanisms of beta-cell failure in type 2 diabetes mellitus, and exploring new educational approaches to promote pathophysiology-based clinical practices. The Endocrine Society has launched a new website to continue the discussion between endocrinologists and primary care physicians on beta-cell pathophysiology in type 2 diabetes and its clinical implications. Join the conversation at http://www.betacellsindiabetes.org (J Clin Endocrinol Metab 95: 4206-4216, 2010)
Metrics
Details
- Title
- Targeting beta-Cell Function Early in the Course of Therapy for Type 2 Diabetes Mellitus
- Creators
- Jack L. Leahy - University of VermontIrl B. Hirsch - University of WashingtonKevin A. Peterson - University of MinnesotaDoron Schneider - Drexel University
- Publication Details
- The journal of clinical endocrinology and metabolism, v 95(9), pp 4206-4216
- Publisher
- Endocrine Soc
- Number of pages
- 11
- Grant note
- Novo Nordisk Endocrine Society
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:000281640300033
- Scopus ID
- 2-s2.0-77956584167
- Other Identifier
- 991019169527704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Endocrinology & Metabolism