Journal article
Targeting the complement system in pancreatic cancer drug resistance: a novel therapeutic approach
Cancer Drug Resistance, v 5(2), pp 317-327
01 Jan 2022
PMID: 35800364
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Pancreatic cancer is ranked as the fourth leading cause of cancer-related mortality and is predicted to become the second leading cause of cancer-related death by 2030. The cause of this high mortality rate is due to pancreatic ductal adenocarcinoma’s rapid progression and metastasis, and development of drug resistance. Today, cancer immunotherapy is becoming a strong candidate to not only treat various cancers but also to combat against chemoresistance. Studies have suggested that complement system pathways play an important role in cancer progression and chemoresistance, especially in pancreatic cancer. A recent report also suggested that several signaling pathways play an important role in causing chemoresistance in pancreatic cancer, major ones including nuclear factor kappa B, signal transducer and activator of transcription 3, c-mesenchymal-epithelial transition factor, and phosphoinositide-3-kinase/protein kinase B. In addition, it has also been proven that the complement system has a very active role in establishing the tumor microenvironment, which would aid in promoting tumorigenesis, progression, metastasis, and recurrence. Interestingly, it has been shown that the downstream products of the complement system directly upregulate inflammatory mediators, which in turn activate these chemo-resistant pathways. Therefore, targeting complement pathways could be an innovative approach to combat against pancreatic cancer drugs resistance. In this review, we have discussed the role of complement system pathways in pancreatic cancer drug resistance and a special focus on the complement as a therapeutic target in pancreatic cancer.
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Details
- Title
- Targeting the complement system in pancreatic cancer drug resistance: a novel therapeutic approach
- Creators
- Naushair Hussain - Department of Biomedical Sciences, Kentucky College of Osteopathic Medicine, University of Pikeville, Pikeville, KY 41501, USA. Department of Education, South College, Knoxville, TN 37902, USA. Department of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, NJ 08103, USA. Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Wyomissing, PA 19610, USADeea Das - Department of Biomedical Sciences, Kentucky College of Osteopathic Medicine, University of Pikeville, Pikeville, KY 41501, USA. Department of Education, South College, Knoxville, TN 37902, USA. Department of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, NJ 08103, USA. Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Wyomissing, PA 19610, USAAtreyi Pramanik - Department of Biomedical Sciences, Kentucky College of Osteopathic Medicine, University of Pikeville, Pikeville, KY 41501, USA. Department of Education, South College, Knoxville, TN 37902, USA. Department of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, NJ 08103, USA. Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Wyomissing, PA 19610, USAManoj K Pandey - Department of Biomedical Sciences, Kentucky College of Osteopathic Medicine, University of Pikeville, Pikeville, KY 41501, USA. Department of Education, South College, Knoxville, TN 37902, USA. Department of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, NJ 08103, USA. Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Wyomissing, PA 19610, USAVivek Joshi - Department of Biomedical Sciences, Kentucky College of Osteopathic Medicine, University of Pikeville, Pikeville, KY 41501, USA. Department of Education, South College, Knoxville, TN 37902, USA. Department of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, NJ 08103, USA. Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Wyomissing, PA 19610, USAKartick C. Pramanik - Department of Biomedical Sciences, Kentucky College of Osteopathic Medicine, University of Pikeville, Pikeville, KY 41501, USA. Department of Education, South College, Knoxville, TN 37902, USA. Department of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, NJ 08103, USA. Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Wyomissing, PA 19610, USA
- Publication Details
- Cancer Drug Resistance, v 5(2), pp 317-327
- Publisher
- OAE Publishing Inc
- Grant note
- Intramural grant funding (Grant # KYCOM210002) from Kentucky College of Osteopathic Medicine (KYCOM), UPIKE to Pramanik KC
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000849629100005
- Scopus ID
- 2-s2.0-85131118171
- Other Identifier
- 991021229907604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology