Journal article
Targeting the homologous recombination pathway by small molecule modulators
Bioorganic & medicinal chemistry letters, v 24(14), pp 3006-3013
15 Jul 2014
PMID: 24856061
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
During the last decade, the use of small molecule (MW <500 Da) compounds that modulate (inhibit or activate) important proteins of different biological pathways became widespread. Recently, the homologous recombination (HR) pathway emerged as a target for such modulators. Development of small molecule modulators pursues two distinct but not mutually exclusive purposes: to create a research tool to study the activities or functions of proteins of interest and to produce drugs targeting specific pathologies. Here, we review the progress of small molecule development in the area of HR.
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Details
- Title
- Targeting the homologous recombination pathway by small molecule modulators
- Creators
- Fei Huang - Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102-1192, United StatesAlexander V Mazin - Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102-1192, United States. Electronic address: amazin@drexelmed.edu
- Publication Details
- Bioorganic & medicinal chemistry letters, v 24(14), pp 3006-3013
- Publisher
- Elsevier; England
- Grant note
- MH097512 / NIMH NIH HHS R01 CA100839 / NCI NIH HHS DA033981 / NIDA NIH HHS R56 CA100839 / NCI NIH HHS CA100839 / NCI NIH HHS R03 MH097512 / NIMH NIH HHS R03 DA033981 / NIDA NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000338809400004
- Scopus ID
- 2-s2.0-84902549722
- Other Identifier
- 991014878337404721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Chemistry, Medicinal
- Chemistry, Organic