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Journal article
Tau: It's Not What You Think
Trends in cell biology, v 29(6), pp 452-461
01 Jun 2019
PMID: 30929793
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Tau is a multifunctional microtubule-associated protein in the neuron. For decades, tau's main function in neurons has been broadly accepted as stabilizing microtubules in the axon; however, this conclusion was reached mainly on the basis of studies performed in vitro and on ectopic expression of tau in non-neuronal cells. The idea has become so prevailing that some disease researchers are even seeking to use microtubule-stabilizing drugs to treat diseases in which tau dissociates from microtubules. Recent work suggests that tau is not a stabilizer of microtubules in the axon, but rather enables axonal microtubules to have long labile domains, in part by outcompeting genuine stabilizers. This new perspective on tau challenges long-standing dogma.
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Details
- Title
- Tau: It's Not What You Think
- Creators
- Peter W. Baas - Drexel UniversityLiang Qiang - Drexel University
- Publication Details
- Trends in cell biology, v 29(6), pp 452-461
- Publisher
- Elsevier
- Number of pages
- 10
- Grant note
- R01NS028785 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) W81XWH-17-1-0504 / Department of Defense; United States Department of Defense Pennsylvania Department of Health CURE grants (via Drexel University) R01 NS28785 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000468076800003
- Scopus ID
- 2-s2.0-85063378927
- Other Identifier
- 991019169797104721
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- Web of Science research areas
- Cell Biology