Tau protects microtubules in the axon from severing by katanin

Liang Qiang; Wenqian Yu; Athena Andreadis; Minhua Luo; Peter W Baas

doi:10.1523/JNEUROSCI.5392-05.2006

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Tau protects microtubules in the axon from severing by katanin

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Tau protects microtubules in the axon from severing by katanin

Liang Qiang, Wenqian Yu, Athena Andreadis, Minhua Luo and Peter W Baas

The Journal of neuroscience, Vol.26(12), pp.3120-3129

22 Mar 2006

DOI: https://doi.org/10.1523/JNEUROSCI.5392-05.2006

PMCID: PMC6674103

PMID: 16554463

Featured in Collection : UN Sustainable Development Goals @ Drexel

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Abstract

Immunohistochemistry

Paclitaxel - pharmacology

Microtubule-Associated Proteins - genetics

Microtubule-Associated Proteins - metabolism

tau Proteins - metabolism

Fibroblasts - ultrastructure

Microtubules - metabolism

Neuronal Plasticity - physiology

RNA Interference

Axons - ultrastructure

Microtubules - ultrastructure

Katanin

Tauopathies - physiopathology

Fibroblasts - metabolism

Cell Line

Cells, Cultured

Adenosine Triphosphatases - metabolism

Axons - metabolism

Rats

Hippocampus - cytology

Down-Regulation - physiology

Hippocampus - metabolism

Tauopathies - metabolism

Animals

Antineoplastic Agents, Phytogenic - pharmacology

Cell Shape - physiology

Microtubules in the axon are more resistant to severing by katanin than microtubules elsewhere in the neuron. We have hypothesized that this is because of the presence of tau on axonal microtubules. When katanin is overexpressed in fibroblasts, the microtubules are severed into short pieces, but this phenomenon is suppressed by the coexpression of tau. Protection against severing is also afforded by microtubule-associated protein 2 (MAP2), which has a tau-like microtubule-binding domain, but not by MAP1b, which has a different microtubule-binding domain. The microtubule-binding domain of tau is required for the protection, but within itself, provides less protection than the entire molecule. When tau (but not MAP2 or MAP1b) is experimentally depleted from neurons, the microtubules in the axon lose their characteristic resistance to katanin. These results, which validate our hypothesis, also suggest a potential explanation for why axonal microtubules deteriorate in neuropathies involving the dissociation of tau from the microtubules.

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Title: Tau protects microtubules in the axon from severing by katanin
Creators: Liang Qiang - Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
Wenqian Yu
Athena Andreadis
Minhua Luo
Peter W Baas
Publication Details: The Journal of neuroscience, Vol.26(12), pp.3120-3129
Publisher: Society for Neuroscience; United States
Resource Type: Journal article
Language: English
Academic Unit: Neurobiology and Anatomy
Identifiers: 991014877862804721

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Collaboration types: Domestic collaboration
Web of Science research areas: Neurosciences

Tau protects microtubules in the axon from severing by katanin

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