Journal article
Technical Standards for Hepatitis B Virus X protein (HBx) Research
Hepatology (Baltimore, Md.), v 61(4), pp 1416-1424
Apr 2015
PMID: 25099228
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Chronic infection with hepatitis B virus (HBV) is a risk factor for developing hepatocellular carcinoma (HCC). The life cycle of HBV is complex and has been difficult to study because HBV does not infect cultured cells. The HBV regulatory X protein (HBx) controls the level of HBV replication and possesses an HCC cofactor role. Attempts to understand the mechanism(s) that underlie HBx effects on HBV replication and HBV-associated carcinogenesis have led to many reported HBx activities that are likely influenced by the assays used. This review summarizes experimental systems commonly used to study HBx functions, describes limitations of these experimental systems that should be considered, and suggests approaches for ensuring the biological relevance of HBx studies.
Metrics
Details
- Title
- Technical Standards for Hepatitis B Virus X protein (HBx) Research
- Creators
- Betty L Slagle - Department of Molecular Virology & Microbiology, Baylor College of Medicine, Houston, TX 77030Ourania M Andrisani - Department of Basic Medical Sciences and Purdue Center for Cancer Research, Purdue University, West Lafayette, IN 47907Michael J Bouchard - Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102Caroline G. L Lee - Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore; Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre Singapore, Singapore 169610, Singapore; Duke-NUS Graduate Medical School Singapore, Singapore 169547, SingaporeJ.-H. James Ou - Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033Aleem Siddiqui - Division of Infectious Diseases, University of California, San Diego, CA 92093
- Publication Details
- Hepatology (Baltimore, Md.), v 61(4), pp 1416-1424
- Publisher
- Wiley
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000352099700035
- Scopus ID
- 2-s2.0-84925353977
- Other Identifier
- 991014877989404721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Gastroenterology & Hepatology