Journal article
Teicoplanin Compared with Vancomycin for Treatment of Experimental Endocarditis Due to Methicillin-Resistant Staphylococcus epidermidis
The Journal of infectious diseases, v 154(1)
Jul 1986
PMID: 2940303
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This study compared teicoplanin with vancomycin without and with gentamicin and/or rifampin for treatment of experimental endocarditis due to methicillin-resistant Staphylococcus epidermidis. In rabbits treated for three days and killed 12 hr after the last doses of antimicrobial agents, no significant difference in reducing bacterial titers of vegetations was detected between vancomycin and teicoplanin without and with gentamicin and/or rifampin. Addition of gentamicin and/or rifampin to vancomycin or teicoplanin significantly reduced bacterial titers of vegetations compared with vancomycin or teicoplanin alone. Addition of rifampin alone or gentamicin plus rifampin was significantly more effective than addition of gentamicin alone. In rabbits treated for three days and killed seven days after the last doses of antimicrobial agents, no significant difference in sterilizing vegetations was detected between vancomycin and teicoplanin with gentamicin and/or rifampin. However, there was a trend (probably due to the longer elimination half-life of teicoplanin in serum) that clearly favored teicoplanin over vancomycin. Teicoplanin plus rifampin without or with gentamicin is at least as effective as vancomycin plus rifampin without or with gentamicin for treatment of experimental endocarditis due to methicillin-resistant S. epidermidis.
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Details
- Title
- Teicoplanin Compared with Vancomycin for Treatment of Experimental Endocarditis Due to Methicillin-Resistant Staphylococcus epidermidis
- Creators
- David W. Galetto - Drexel UniversityJerome A. Boscia - Drexel UniversityWilliam D. Kobasa - Drexel UniversityDonald Kaye - Drexel University
- Publication Details
- The Journal of infectious diseases, v 154(1)
- Publisher
- The University of Chicago Press
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate)
- Web of Science ID
- WOS:A1986C823200009
- Scopus ID
- 2-s2.0-0022450623
- Other Identifier
- 991019184308804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Immunology
- Infectious Diseases
- Microbiology