Journal article
Temperature Evolution during Compaction of Pharmaceutical Powders
Journal of pharmaceutical sciences, v 97(8), pp 3291-3304
Aug 2008
PMID: 17969108
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A numerical approach to the prediction of temperature evolution in tablet compaction is presented here. It is based on a coupled thermomechanical finite element analysis and a calibrated Drucker–Prager Cap model. This approach is capable of predicting transient temperatures during compaction, which cannot be assessed by experimental techniques due to inherent test limitations. Model predictions are validated with infrared (IR) temperature measurements of the top tablet surface after ejection and match well with experiments. The dependence of temperature fields on speed and degree of compaction are naturally captured. The estimated transient temperatures are maximum at the end of compaction at the center of the tablet and close to the die wall next to the powder/die interface.
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Details
- Title
- Temperature Evolution during Compaction of Pharmaceutical Powders
- Creators
- Antonios Zavaliangos - Drexel University, Materials Science and EngineeringSteve Galen - Drexel University, Materials Science and EngineeringJohn Cunningham - Johnson & Johnson (United States, Spring House)Denita Winstead - Johnson & Johnson (United States, Spring House)
- Publication Details
- Journal of pharmaceutical sciences, v 97(8), pp 3291-3304
- Publisher
- Elsevier
- Number of pages
- 14
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Web of Science ID
- WOS:000258081100030
- Scopus ID
- 2-s2.0-52449109916
- Other Identifier
- 991014877676004721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Chemistry, Medicinal
- Chemistry, Multidisciplinary
- Pharmacology & Pharmacy