Journal article
Temperature, Myocardial Infarction, and Mortality Effect Modification by Individual- and Area-level Characteristics
Epidemiology (Cambridge, Mass.), v 24(3), pp 439-446
May 2013
PMID: 23462524
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Although several studies have examined associations between temperature and cardiovascular-disease-related mortality, fewer have investigated the association between temperature and the development of acute myocardial infarction (MI). Moreover, little is known about who is most susceptible to the effects of temperature.
Methods: We analyzed data from the Worcester Heart Attack Study, a community-wide investigation of acute MI in residents of the Worcester (MA) metropolitan area. We used a case-crossover approach to examine the association of apparent temperature with acute MI occurrence and with all-cause in-hospital and postdischarge mortality. We examined effect modification by sociodemographic characteristics, medical history, clinical complications, and physical environment.
Results: A decrease in an interquartile range in apparent temperature was associated with an increased risk of acute MI on the same day (hazard ratio = 1.15 [95% confidence interval = 1.01-1.31]). Extreme cold during the 2 days prior was associated with an increased risk of acute MI (1.36 [1.07-1.74]). Extreme heat during the 2 days prior was also associated with an increased risk of mortality (1.44 [1.06-1.96]). Persons living in areas with greater poverty were more susceptible to heat.
Conclusions: Exposure to cold increased the risk of acute MI, and exposure to heat increased the risk of dying after an acute MI. Local area vulnerability should be accounted for as cities prepare to adapt to weather fluctuations as a result of climate change. (Epidemiology 2013; 24: 439-446)
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Details
- Title
- Temperature, Myocardial Infarction, and Mortality Effect Modification by Individual- and Area-level Characteristics
- Creators
- Jaime Madrigano - Harvard UniversityMurray A. Mittleman - Beth Israel Deaconess Medical CenterAndrea Baccarelli - Harvard UniversityRobert Goldberg - University of Massachusetts Chan Medical SchoolSteven Melly - Harvard UniversityStephanie von Klot - Helmholtz Zentrum MünchenJoel Schwartz - Harvard University
- Publication Details
- Epidemiology (Cambridge, Mass.), v 24(3), pp 439-446
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 8
- Grant note
- RO1 HL35434; T32ES07069; T32ES016645 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA RD 83479801 / USEPA; United States Environmental Protection Agency T32ES007069 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) R01HL035434 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000316998800016
- Scopus ID
- 2-s2.0-84876292182
- Other Identifier
- 991021875474704721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health