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Temperature preferences and the effect of changes in serotonin in maturing mice
Journal article   Peer reviewed

Temperature preferences and the effect of changes in serotonin in maturing mice

Cecilie Goodrich and Carole Wilk
Physiology & behavior, v 26(6), pp 1041-1047
01 Jan 1981
PMID: 6456470

Abstract

Neonatal mice Serotonin Temperature preference Thermoregulation
Behavior of maturing mice in a 20 cm long thermal gradient is described. Mean preferred temperatures (T pref) under standard test conditions ranged from about 29° to 31° in untreated mice aged 3, 7, 10, and 14 days postpartum, which is similar to the temperature maintained in the nest by parent mice. Increased serotonin (5-HT) after injection of the precursor 5-hydroxytryptophan (30 mg/kg) was generally associated with increasted T pref (7 and 10 days) as compared with vehicle injected littermate controls in a double-blind study. Depletion of 5-HT following p-chlorophenylalanine (400 mg/kg) was associated with decreased T pref (3 and 7 days). Relationships with body temperature and thermoregulation are discussed and handling cautions are presented.

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Web of Science research areas
Behavioral Sciences
Psychology, Biological
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