Journal article
Temporal Dynamics of Brain Tissue Nitric Oxide during Functional Forepaw Stimulation in Rats
NeuroImage (Orlando, Fla.), v 18(1), pp 1-9
2003
PMID: 12507439
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We report the first dynamic measurements of tissue nitric oxide (NO) during functional activation of rat somatosensory cortex by electrical forepaw stimulation. Cortical tissue NO was measured electrochemically with rapid-responding recessed microelectrodes (tips <10 μm). Simultaneous blood flow measurements were made by laser–Doppler flowmetry (LDF). NO immediately increased, reaching a peak 125.5 ± 32.8 (SE) nM above baseline (
P < 0.05) within 400 ms after stimulus onset, preceding any LDF changes, and then returned close to prestimulus levels after 2 s (123 signal-averaged trials, 12 rats). Blood flow began rising after a 1-s delay, reaching a peak just before electrical stimulation was ended at
t = 4 s. A consistent poststimulus NO undershoot was observed as LDF returned to baseline. These findings complement our previous study (B. M. Ances
et al., 2001,
Neurosci. Lett. 306, 106–110) in which a transient decrease in rat somatosensory cortex tissue oxygen partial pressure was found to precede blood flow increases during functional activation.
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Details
- Title
- Temporal Dynamics of Brain Tissue Nitric Oxide during Functional Forepaw Stimulation in Rats
- Creators
- Donald G. Buerk - University of PennsylvaniaBeau M. Ances - University of PennsylvaniaJoel H. Greenberg - University of PennsylvaniaJohn A. Detre - University of Pennsylvania
- Publication Details
- NeuroImage (Orlando, Fla.), v 18(1), pp 1-9
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000180015200001
- Scopus ID
- 2-s2.0-0037227492
- Other Identifier
- 991019231741504721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Neuroimaging
- Neurosciences
- Radiology, Nuclear Medicine & Medical Imaging