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Published, Version of Record (VoR)Open Access (License Unspecified), Open
Journal article
Temporal Global Changes in Gene Expression during Temperature Transition in Yersinia pestis
Journal of bacteriology, v 186(18), pp 6298-6305
01 Sep 2004
PMID: 15342600
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
DNA microarrays encompassing the entire genome of
Yersinia pestis
were used to characterize global regulatory changes during steady-state vegetative growth occurring after shift from 26 to 37°C in the presence and absence of Ca
2+
. Transcriptional profiles revealed that 51, 4, and 13 respective genes and open reading frames (ORFs) on pCD, pPCP, and pMT were thermoinduced and that the majority of these genes carried by pCD were downregulated by Ca
2+
. In contrast, Ca
2+
had little effect on chromosomal genes and ORFs, of which 235 were thermally upregulated and 274 were thermally downregulated. The primary consequence of these regulatory events is profligate catabolism of numerous metabolites available in the mammalian host.
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Details
- Title
- Temporal Global Changes in Gene Expression during Temperature Transition in Yersinia pestis
- Creators
- Vladimir L. Motin - Lawrence Livermore National LaboratoryAnca M. Georgescu - Lawrence Livermore National LaboratoryJoseph P. Fitch - Lawrence Livermore National LaboratoryPauline P. Gu - Lawrence Livermore National LaboratoryDavid O. Nelson - Lawrence Livermore National LaboratoryShalini L. Mabery - Lawrence Livermore National LaboratoryJanine B. Garnham - Lawrence Livermore National LaboratoryBahrad A. Sokhansanj - Lawrence Livermore National LaboratoryLinda L. Ott - Lawrence Livermore National LaboratoryMatthew A. Coleman - Lawrence Livermore National LaboratoryJeffrey M. Elliott - Lawrence Livermore National LaboratoryLaura M. Kegelmeyer - Lawrence Livermore National LaboratoryAndrew J. Wyrobek - Lawrence Livermore National LaboratoryThomas R. Slezak - Lawrence Livermore National LaboratoryRobert R. Brubaker - Michigan State UniversityEmilio Garcia - Lawrence Livermore National Laboratory
- Publication Details
- Journal of bacteriology, v 186(18), pp 6298-6305
- Publisher
- American Society for Microbiology
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Electrical and Computer Engineering
- Web of Science ID
- WOS:000223699900036
- Scopus ID
- 2-s2.0-4444360796
- Other Identifier
- 991019187065504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Microbiology