Journal article
Temporal Lobe and Frontal-Subcortical Dissociations in Non-Demented Parkinson's Disease with Verbal Memory Impairment
PloS one, v 10(7), pp e0133792-e0133792
24 Jul 2015
PMID: 26208170
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective
The current investigation examined verbal memory in idiopathic non-dementia Parkinson's disease and the significance of the left entorhinal cortex and left entorhinal-retrosplenial region connections (via temporal cingulum) on memory impairment in Parkinson's disease.
Methods
Forty non-demented Parkinson's disease patients and forty non-Parkinson's disease controls completed two verbal memory tests - a wordlist measure (Philadelphia repeatable Verbal Memory Test) and a story measure (Logical Memory). All participants received T1-weighted and diffusion magnetic resonance imaging (3T; Siemens) sequences. Left entorhinal volume and left entorhinal-retrosplenial connectivity (temporal cingulum edge weight) were the primary imaging variables of interest with frontal lobe thickness and subcortical structure volumes as dissociating variables.
Results
Individuals with Parkinson's disease showed worse verbal memory, smaller entorhinal volumes, but did not differ in entorhinal-retrosplenial connectivity. For Parkinson's disease entorhinal-retrosplenial edge weight had the strongest associations with verbal memory. A subset of Parkinson's disease patients (23%) had deficits (z-scores < -1.5) across both memory measures. Relative to non-impaired Parkinson's peers, this memory-impaired group had smaller entorhinal volumes.
Discussion
Although entorhinal cortex volume was significantly reduced in Parkinson's disease patients relative to non-Parkinson's peers, only white matter connections associated with the entorhinal cortex were significantly associated with verbal memory performance in our sample. There was also no suggestion of contribution from frontal-subcortical gray or frontal white matter regions. These findings argue for additional investigation into medial temporal lobe gray and white matter connectivity for understanding memory in Parkinson's disease.
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Details
- Title
- Temporal Lobe and Frontal-Subcortical Dissociations in Non-Demented Parkinson's Disease with Verbal Memory Impairment
- Creators
- Jared J. Tanner - University of Florida HealthThomas H. Mareci - University of FloridaMichael S. Okun - University of FloridaDawn Bowers - University of Florida HealthDavid J. Libon - Drexel UniversityCatherine C. Price - University of Florida Health
- Publication Details
- PloS one, v 10(7), pp e0133792-e0133792
- Publisher
- Public Library Science
- Number of pages
- 13
- Grant note
- UL1TR000064 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) K23NS60660; R01NR014810; R01NS082386 / National Institutes of Health National Institute of Neurological Disorders and Stroke; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) UL1TR000064 / National Institutes of Health/National Center for Advancing Translational Sciences Clinical and Translational Science Award Center for Movement Disorders and Neurorestoration K23NS060660 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000358622000145
- Scopus ID
- 2-s2.0-84941710748
- Other Identifier
- 991021901012504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences