Journal article
Temporal dynamics of the partial pressure of brain tissue oxygen during functional forepaw stimulation in rats
Neuroscience letters, v 306(1), pp 106-110
2001
PMID: 11403969
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The partial pressure of tissue oxygen (pO
2) was measured in rat somatosensory cortex during periodic electrical forepaw stimulation of either 1 min or 4 s in duration, and correlated with simultaneous laser Doppler flowmetry. For both stimulus durations, a transient decrease in tissue pO
2 preceded blood flow changes, followed by a peak in blood flow and an overshoot in tissue pO
2. With protracted stimulation, tissue pO
2 remained only slightly above pre-stimulus baseline, while blood flow was maintained at a reduced plateau phase. A sustained post-stimulus undershoot in tissue pO
2 was observed only for the 1 min stimulus. These findings suggest a complex dynamic relationship between oxygen utilization and blood flow.
Metrics
Details
- Title
- Temporal dynamics of the partial pressure of brain tissue oxygen during functional forepaw stimulation in rats
- Creators
- Beau M Ances - University of PennsylvaniaDonald G Buerk - University of PennsylvaniaJoel H Greenberg - University of PennsylvaniaJohn A Detre - University of Pennsylvania
- Publication Details
- Neuroscience letters, v 306(1), pp 106-110
- Publisher
- Elsevier Ireland Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000169465800027
- Scopus ID
- 2-s2.0-0035933660
- Other Identifier
- 991019231632604721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Neurosciences