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Temporal order memory differences in Alzheimer's disease and vascular dementia
Journal article

Temporal order memory differences in Alzheimer's disease and vascular dementia

Benjamin M Hampstead, David J Libon, Stephen T Moelter, Thomas Swirsky-Sacchetti, Ludo Scheffer, Steven M Platek and Douglas Chute
Journal of clinical and experimental neuropsychology, v 32(6), pp 645-654
07 Jul 2010
PMID: 20087810

Abstract

Small vessel ischemic disease Working memory Mild cognitive impairment Leukoaraiosis Sequential memory
Determining the order of events is essential for accurate memory recollection: an ability previously linked to both frontal and medial temporal functioning. Frontal-subcortical and medial temporal dysfunction typify vascular dementia (VaD) and Alzheimer's disease (AD), respectively. Therefore, we assessed patients' ordering abilities using a novel sequencing task that progressively increased memory load. VaD patients made more errors and selected more previously encountered stimuli than did AD. Curve analysis revealed a general decline in ordering for VaD whereas error production in AD is more dependent on memory load. These findings generally support the role of frontal-subcortical functioning in temporal order memory.

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20 citations in Scopus

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Collaboration types
Domestic collaboration
Web of Science research areas
Clinical Neurology
Psychology
Psychology, Clinical
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