Journal article
Tendon Biomechanics and Crimp Properties Following Fatigue Loading Are Influenced by Tendon Type and Age in Mice
Journal of orthopaedic research, v 38(1), pp 36-42
01 Jan 2020
PMID: 31286548
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In tendon, type-I collagen assembles together into fibrils, fibers, and fascicles that exhibit a wavy or crimped pattern that uncrimps with applied tensile loading. This structural property has been observed across multiple tendons throughout aging and may play an important role in tendon viscoelasticity, response to fatigue loading, healing, and development. Previous work has shown that crimp is permanently altered with the application of fatigue loading. This opens the possibility of evaluating tendon crimp as a clinical surrogate of tissue damage. The purpose of this study was to determine how fatigue loading in tendon affects crimp and mechanical properties throughout aging and between tendon types. Mouse patellar tendons (PT) and flexor digitorum longus (FDL) tendons were fatigue loaded while an integrated plane polariscope simultaneously assessed crimp properties at P150 and P570 days of age to model mature and aged tendon phenotypes (N = 10-11/group). Tendon type, fatigue loading, and aging were found to differentially affect tendon mechanical and crimp properties. FDL tendons had higher modulus and hysteresis, whereas the PT showed more laxity and toe region strain throughout aging. Crimp frequency was consistently higher in FDL compared with PT throughout fatigue loading, whereas the crimp amplitude was cycle dependent. This differential response based on tendon type and age further suggests that the FDL and the PT respond differently to fatigue loading and that this response is age-dependent. Together, our findings suggest that the mechanical and structural effects of fatigue loading are specific to tendon type and age in mice.
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Details
- Title
- Tendon Biomechanics and Crimp Properties Following Fatigue Loading Are Influenced by Tendon Type and Age in Mice
- Creators
- Andrey Zuskov - Wake Forest UniversityBenjamin R. Freedman - Harvard UniversityJoshua A. Gordon - University of PennsylvaniaJoseph J. Saryer - Drexel Univ, Dept Biomed Engn, Philadelphia, PA 19104 USAMark R. Buckley - University of RochesterLouis J. Soslowsky - University of PennsylvaniaJoseph J Sarver - School of Biomedical Engineering, Science, and Health Systems (1997-)
- Publication Details
- Journal of orthopaedic research, v 38(1), pp 36-42
- Publisher
- Wiley
- Number of pages
- 7
- Grant note
- F32 AG057135-02 / NIH/NIA; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) P30 AR050950 / NIH/NIAMS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) National Science Foundation Graduate Fellowship; National Science Foundation (NSF)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000479379200001
- Scopus ID
- 2-s2.0-85076498957
- Other Identifier
- 991019176646804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Orthopedics