Journal article
Testicular inflammation and infertility: Could chlamydial infections be contributing?
American journal of reproductive immunology (1989), v 84(3), pp e13286-n/a
01 Sep 2020
PMID: 32533905
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Despite the global incidence of both male infertility and sexually transmitted infections rising each year, the relationship between the two is relatively unstudied.Chlamydiais the most common bacterial sexually transmitted pathogen; however, the majority of research remains focussed on women, while the role of infection and resulting immunopathology in male factor infertility is largely unknown.Chlamydiawas found in testicular biopsies from asymptomatic men with idiopathic infertility, which highlights this potential role. In animal models, testicularChlamydia, and potentially other bacterial and viral infections, cause histopathology that is likely to adversely affect spermatogenesis and fertility. This likely occurs through infiltration of inflammatory cells, functional dysregulation of immunosuppressive testicular macrophages and Sertoli cells and destruction of key testicular cell types including sperm progenitors. Here, testicular damage due to infection and/or inflammation is reviewed, as it represents a probable underestimated and unrecognized factor leading to male infertility.
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Details
- Title
- Testicular inflammation and infertility: Could chlamydial infections be contributing?
- Creators
- Emily R. Bryan - Queensland University of TechnologyJay Kim - Queensland University of TechnologyKenneth W. Beagley - Queensland University of TechnologyAlison J. Carey - Queensland University of Technology
- Publication Details
- American journal of reproductive immunology (1989), v 84(3), pp e13286-n/a
- Publisher
- Wiley
- Number of pages
- 9
- Grant note
- APP1145825 / National Health and Medical Research Council; National Health and Medical Research Council (NHMRC) of Australia
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics; College of Medicine; Drexel University
- Web of Science ID
- WOS:000542393800001
- Scopus ID
- 2-s2.0-85087143479
- Other Identifier
- 991020099919004721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Immunology
- Reproductive Biology