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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Testing multiple levels of influence in the intergenerational transmission of alcohol disorders from a developmental perspective: the example of alcohol use promoting peers and μ-opioid receptor M1 variation
Development and psychopathology, v 24(3), pp 953-967
Aug 2012
PMID: 22781865
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This study examined the interplay between the influence of peers who promote alcohol use and μ-opioid receptor M1 (OPRM1) genetic variation in the intergenerational transmission of alcohol use disorder (AUD) symptoms while separating the "traitlike" components of AUD symptoms from their age-specific manifestations at three ages from emerging adulthood (17-23 years) to adulthood (29-40 years). The results for males were consistent with genetically influenced peer selection mechanisms as mediators of parent alcoholism effects. Male children of alcoholics were less likely to be carriers of the G allele in single nucleotide polymorphism A118G (rs1799971), and those who were homozygous for the A allele were more likely to affiliate with alcohol use promoting peers who increased the risk for AUD symptoms at all ages. There was evidence for women of an interaction between OPRM1 variation and peer affiliations but only at the earliest age band. Peer influences had stronger effects among women who were G-carriers. These results illustrate the complex ways in which the interplay between influences at multiple levels of analysis can underlie the intergenerational transmission of alcohol disorders as well as the importance of considering age and gender differences in these pathways.
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Details
- Title
- Testing multiple levels of influence in the intergenerational transmission of alcohol disorders from a developmental perspective: the example of alcohol use promoting peers and μ-opioid receptor M1 variation
- Creators
- Laurie Chassin - Arizona State UniversityMatthew R LeeYoung Il ChoFrances L WangArpana AgrawalKenneth J SherMichael T Lynskey
- Publication Details
- Development and psychopathology, v 24(3), pp 953-967
- Publisher
- Cambridge University Press
- Grant note
- 2P60AA011998 / NIAAA NIH HHS K05 AA017242 / NIAAA NIH HHS R01 AA016213 / NIAAA NIH HHS AA016213 / NIAAA NIH HHS P60 AA011998 / NIAAA NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000306680100017
- Scopus ID
- 2-s2.0-84863975110
- Other Identifier
- 991020547319204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Psychology, Developmental