Journal article
Tetrahydroisoquinoline 1-carboxamides as growth hormone secretagogues
Bioorganic & medicinal chemistry letters, v 15(7), pp 1799-1802
01 Apr 2005
PMID: 15780609
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Several novel series of tetrahydroisoquinoline 1-carboxamides (i.e.,
12a–
E2) were prepared and shown to be potent growth hormone (GH) secretagogues.
Several novel series of tetrahydroisoquinoline 1-carboxamides were prepared and shown to be potent growth hormone (GH) secretagogues. Among them, carbamate
12a–
E2 displays excellent in vivo activity by increasing plasma GH 10-fold in an anesthetized IV rat model.
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Details
- Title
- Tetrahydroisoquinoline 1-carboxamides as growth hormone secretagogues
- Creators
- James J. Li - Bristol-Myers Squibb (United States)Haixia Wang - Bristol-Myers Squibb (United States)Fucheng Qu - Bristol-Myers Squibb (United States)Christa Musial - Bristol-Myers Squibb (Germany)Joseph A. Tino - Bristol-Myers Squibb (Germany)Jeffrey A. Robl - Bristol-Myers Squibb (United States)Dorothy Slusarchyk - Bristol-Myers Squibb (United States)Rajasree Golla - Bristol-Myers Squibb (Germany)Ramakrishna Seethala - Bristol-Myers Squibb (United States)Kenneth Dickinson - Bristol-Myers Squibb (United States)Leah Giupponi - Bristol-Myers Squibb (United States)Gary Grover - Bristol-Myers Squibb (United States)Paul Sleph - Bristol-Myers Squibb (United States)Neil Flynn - Bristol-Myers Squibb (United States)Brian J. Murphy - Bristol-Myers Squibb (United States)David Gordon - Bristol-Myers Squibb (United States)Melissa Kung - Bristol-Myers Squibb (Germany)Robert Stoffel - Bristol-Myers Squibb (United States)
- Publication Details
- Bioorganic & medicinal chemistry letters, v 15(7), pp 1799-1802
- Publisher
- Elsevier
- Number of pages
- 4
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000228125300007
- Scopus ID
- 2-s2.0-20144380823
- Other Identifier
- 991021903315304721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Chemistry, Medicinal
- Chemistry, Organic