Journal article
Tetrazole based amides as growth hormone secretagogues
Bioorganic & medicinal chemistry letters, v 18(8), pp 2536-2539
15 Apr 2008
PMID: 18378446
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A novel series of
N1 substituted tetrazole amides were prepared and showed to be potent growth hormone (GH) secretagogues. Among them, hydroxyl containing analog
31 displayed excellent in vivo activity by increasing plasma GH 10-fold in an anesthetized IV rat model.
A novel series of
N1 substituted tetrazole amides were prepared and showed to be potent growth hormone (GH) secretagogues. Among them, hydroxyl containing analog
31 displayed excellent in vivo activity by increasing plasma GH 10-fold in an anesthetized IV rat model.
Metrics
Details
- Title
- Tetrazole based amides as growth hormone secretagogues
- Creators
- James J. Li - Bristol-Myers Squibb (United States)Haixia Wang - Bristol-Myers Squibb (United States)Jun Li - Bristol-Myers Squibb (United States)Fucheng Qu - Bristol-Myers Squibb (United States)Stephen G. Swartz - Bristol-Myers Squibb (Germany)Andrés S. Hernández - Bristol-Myers Squibb (United States)Scott A. Biller - Bristol-Myers Squibb (Germany)Jeffrey A. Robl - Bristol-Myers Squibb (United States)Joseph A. Tino - Bristol-Myers Squibb (Germany)Dorothy Slusarchyk - Bristol-Myers Squibb (United States)Ramakrishna Seethala - Bristol-Myers Squibb (United States)Paul Sleph - Bristol-Myers Squibb (United States)Mujing Yan - Bristol-Myers Squibb (United States)Gary Grover - Bristol-Myers Squibb (United States)Neil Flynn - Bristol-Myers Squibb (United States)Brian J. Murphy - Bristol-Myers Squibb (United States)David Gordon - Bristol-Myers Squibb (United States)
- Publication Details
- Bioorganic & medicinal chemistry letters, v 18(8), pp 2536-2539
- Publisher
- Elsevier
- Number of pages
- 4
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000255246400003
- Scopus ID
- 2-s2.0-41849151129
- Other Identifier
- 991021903122404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Chemistry, Medicinal
- Chemistry, Organic