Journal article
Thalamic Single-Unit and Local Field Potential Activity in Tourette Syndrome
Movement disorders, v 25(3), pp 300-308
15 Feb 2010
PMID: 20108375
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Deep brain stimulation (DBS) of the ventralis oralis (VO) complex of the thalamus improves tics in patients with Tourette syndrome (TS). To neurophysiologically describe the VO complex we recorded, in seven patients with TS undergoing DBS electrode implantation, single-unit activity during surgery and local field potentials (LFPs) a few days after Surgery. Single unit recordings showed that the VO complex is characterized by a localized pattern of bursting neuronal activity. LFP spectra demonstrated that VO of TS patients has a prominent oscillatory activity at low frequencies (2-7 Hz) and in the a-band (8-13 Hz), and a virtually absent beta activity. In each patient, the main LFP frequency significantly correlated with single-unit interburst frequency. In conclusion, we observed an oscillatory bursting activity in the VO as target region in patients with severe TS Undergoing DBS surgery. (C) 2010 Movement Disorder Society
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Details
- Title
- Thalamic Single-Unit and Local Field Potential Activity in Tourette Syndrome
- Creators
- Sara Marceglia - Ospedale MaggioreDomenico Servello - Vita-Salute San Raffaele UniversityGuglielmo Foffani - Drexel UniversityMauro Porta - Vita-Salute San Raffaele UniversityMarco Sassi - Vita-Salute San Raffaele UniversitySimona Mrakic-Sposta - Ospedale MaggioreManuela Rosa - Ospedale MaggioreSergio Barbieri - Ospedale MaggioreAlberto Priori - Ospedale Maggiore
- Publication Details
- Movement disorders, v 25(3), pp 300-308
- Publisher
- Wiley
- Number of pages
- 9
- Grant note
- Tourette Syndrome Association Ministero della Sanita (Italy) Ministero dell'Universita e della Ricerca Scientifica (Italy); Ministry of Education, Universities and Research (MIUR) Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena (Milan, Italy) IRCCS Galeazzi (Milan, Italy) University degli Studi di Milano (Italy)
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000276136900008
- Scopus ID
- 2-s2.0-77649084596
- Other Identifier
- 991019353722704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology