Journal article
Thapsigargin enhances carotid body chemosensory discharge in response to hypoxia in zero [Ca2+]e: evidence for intracellular Ca2+ release
Brain research, v 709(1), pp 141-144
12 Feb 1996
PMID: 8869566
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To test the hypothesis that Ca2+ is released from intracellular store in the carotid body glomus cells during hypoxia, we stimultaneously measured chemosensory discharge and tissue PO2 of perfused-superfused cat carotid body before and during flow interruption in the presence and absence of extracellular [Ca2+] with and without thapsigargin (1-10 microM). Ca(2+)-free solution increased the latency of sensory response, and decreased the rate of rise and peak activity but thapsigargin significantly influenced these responses, without affecting oxygen consumption. Since thapsigargin depletes the intracellular Ca2+ store, and since Ca2+ is needed for the sensory discharge, these results suggest that intracellular release and influx of Ca2+ occur during hypoxia.
Metrics
Details
- Title
- Thapsigargin enhances carotid body chemosensory discharge in response to hypoxia in zero [Ca2+]e: evidence for intracellular Ca2+ release
- Creators
- S Lahiri - University of PennsylvaniaS Osanai - University of PennsylvaniaD G Buerk - University of PennsylvaniaA Mokashi - University of PennsylvaniaD K Chugh - University of Pennsylvania
- Publication Details
- Brain research, v 709(1), pp 141-144
- Publisher
- Elsevier
- Grant note
- HL 51080-02 / NHLBI NIH HHS T32 HL 07027-21 / NHLBI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:A1996TX90900017
- Scopus ID
- 2-s2.0-0030058187
- Other Identifier
- 991019231743304721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Neurosciences