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Journal article
The 5-HT 1A agonist 8-OH-DPAT attenuates the satiating action of cholecystokinin
Pharmacology, biochemistry and behavior, v 42(3), pp 541-543
1992
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Abstract
To investigate the dependence of the satiating action of cholecystokinin (CCK) on serotonergic action at central 5-HT receptors, we examined the effect of systemic pretreatment with 8-OH-DPAT (a 5-HT
1A agonist that decreases central 5-HT synthesis and release via an action at somatodendritic autoreceptors in the brainstem raphe) on the suppression of food intake induced by systemic administration of cholecystokinin octapeptide (CKK-8). 8-OH-DPAT significantly attenuated the satiating action of CKK-8. This result is consistent with the hypothesis that peripherally acting CCK recruits central serotonergic processes to elicit normal satiety.
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Details
- Title
- The 5-HT 1A agonist 8-OH-DPAT attenuates the satiating action of cholecystokinin
- Creators
- B. Poeschla - Cornell UniversityJ. Gibbs - Cornell UniversityK.J. Simansky - York College of PennsylvaniaG.P. Smith - Cornell University
- Publication Details
- Pharmacology, biochemistry and behavior, v 42(3), pp 541-543
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1992JA63600023
- Scopus ID
- 2-s2.0-0026611486
- Other Identifier
- 991019183935104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Behavioral Sciences
- Neurosciences
- Pharmacology & Pharmacy