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Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
The Airway Microbiome at Birth
Scientific reports, v 6(1), pp 31023-31023
04 Aug 2016
PMID: 27488092
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Alterations of pulmonary microbiome have been recognized in multiple respiratory disorders. It is critically important to ascertain if an airway microbiome exists at birth and if so, whether it is associated with subsequent lung disease. We found an established diverse and similar airway microbiome at birth in both preterm and term infants, which was more diverse and different from that of older preterm infants with established chronic lung disease (bronchopulmonary dysplasia). Consistent temporal dysbiotic changes in the airway microbiome were seen from birth to the development of bronchopulmonary dysplasia in extremely preterm infants. Genus
Lactobacillus
was decreased at birth in infants with chorioamnionitis and in preterm infants who subsequently went on to develop lung disease. Our results, taken together with previous literature indicating a placental and amniotic fluid microbiome, suggest fetal acquisition of an airway microbiome. We speculate that the early airway microbiome may prime the developing pulmonary immune system, and dysbiosis in its development may set the stage for subsequent lung disease.
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Details
- Title
- The Airway Microbiome at Birth
- Creators
- Charitharth Vivek Lal - University of Alabama at BirminghamColm Travers - University of Alabama at BirminghamZubair H. Aghai - Thomas Jefferson UniversityPeter Eipers - University of Alabama at BirminghamTamas Jilling - University of Alabama at BirminghamBrian Halloran - University of Alabama at BirminghamWaldemar A. Carlo - University of Alabama at BirminghamJordan Keeley - University of Alabama at BirminghamGabriel Rezonzew - University of Alabama at BirminghamRanjit Kumar - University of Alabama at BirminghamCasey Morrow - University of Alabama at BirminghamVineet Bhandari - Drexel UniversityNamasivayam Ambalavanan - University of Alabama at Birmingham
- Publication Details
- Scientific reports, v 6(1), pp 31023-31023
- Publisher
- Nature Publishing Group
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000380894700001
- Scopus ID
- 2-s2.0-84982860176
- Other Identifier
- 991019167813104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pediatrics