Journal article
The Assessment of Post-COVID Fatigue and Its Relationship to the Severity and Duration of Acute COVID Illness
JOURNAL OF CLINICAL MEDICINE, v 12(18), 5910
Sep 2023
PMID: 37762851
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Emerging data suggests that COVID-19 is associated with fatigue well beyond the acute illness period. The present analysis aimed to: (1) characterize the prevalence and incidence of high fatigue at baseline and follow-up; (2) examine the impact of COVID-19 diagnosis on fatigue level following acute illness; and (3) examine the impact of acute COVID-19 symptom severity and duration on fatigue at follow-up. Subjects (n = 1417; 81.0% female; 83.3% White; X over bar age = 43.6 years) completed the PROMIS-Fatigue during the initial wave of the pandemic at baseline (April-June 2020) and 9-month follow-up (January-March 2021). A generalized linear model (binomial distribution) was used to examine whether COVID-19 positivity, severity, and duration were associated with higher fatigue level at follow-up. Prevalence of high fatigue at baseline was 21.88% and 22.16% at follow-up, with 8.12% new cases at follow-up. Testing positive for COVID-19 was significantly associated with higher fatigue at follow-up. COVID-19 symptom duration and severity were significantly associated with increased fatigue at follow-up. COVID-19 symptom duration and severity during acute illness may precipitate longer-term fatigue, which could have implications for treatment planning and future research. Future studies should further evaluate the relationship between symptom severity, duration, and fatigue.
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Details
- Title
- The Assessment of Post-COVID Fatigue and Its Relationship to the Severity and Duration of Acute COVID Illness
- Publication Details
- JOURNAL OF CLINICAL MEDICINE, v 12(18), 5910
- Publisher
- MDPI; BASEL
- Grant note
- This work was supported by the National Institutes of Health: Muench: 5T32HL00795320(NHLBI); Perlis: K24AG055602 (NIA); Vargas: K23HL141581 (NHLBI), R25HL10544 (NHLBI).
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:001074034400001
- Scopus ID
- 2-s2.0-85172792670
- Other Identifier
- 991021861199204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences