Journal article
The Association between Long-Term Air Pollution and Urinary Catecholamines: Evidence from the Multi-Ethnic Study of Atherosclerosis
Environmental health perspectives, v 127(5), pp 57007-57007
May 2019
PMID: 31095432
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Autonomic nervous system effects have been hypothesized as a mechanism of air pollutant health effects, though scant prior epidemiologic research has examined the association between air pollutants and catecholamines.
To examine the association of long-term air pollutants with three urinary catecholamines: dopamine (DA), epinephrine (EPI), and norepinephrine (NE). As a secondary aim, we also examined the association between short-term (or acute) exposure to fine particulate matter [particulate matter with aerodynamic diameter [Formula: see text] ([Formula: see text])] and those catecholamines.
We used data from the Multi-Ethnic Study of Atherosclerosis (MESA) and two of its ancillary studies, the MESA Air Pollution Study and the MESA Stress Study, to provide exposure and outcome data. DA, EPI, and NE from urine samples were collected from 2004 to 2006 from 1,002 participants in the New York, New York, and Los Angeles, California, study sites. Spatiotemporal models incorporated cohort-specific monitoring and estimated annual average pollutant concentrations ([Formula: see text], [Formula: see text], [Formula: see text] and black carbon) at participants' homes the year prior to urine collection. Secondarily, short-term [Formula: see text] was evaluated (day of, day prior, and 2- to 5-d lags prior to urine collection). Several covariates were considered confounders (age, race, sex, site, socioeconomic status, cardiovascular disease risk factors, psychosocial stressors, and medication use) in linear regression models.
A [Formula: see text] higher annual [Formula: see text] concentration was associated with 6.3% higher mean EPI level [95% confidence interval (CI): 0.3%, 12.6%]. A 2-[Formula: see text] higher annual ambient [Formula: see text] concentration was associated with 9.1% higher mean EPI (95% CI: 3.2%, 15.3%) and 4.4% higher DA level (95% CI: 1%, 7.9%). [Formula: see text], black carbon, and short-term [Formula: see text] exposures were not significantly associated with any of the catecholamines.
We found an association between EPI and long-term concentrations of [Formula: see text] and [Formula: see text] and an association between DA and long-term ambient [Formula: see text]. These novel findings provide modest support for the hypothesis that air pollutant exposures are related to sympathetic nervous system activation. https://doi.org/10.1289/EHP3286.
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Details
- Title
- The Association between Long-Term Air Pollution and Urinary Catecholamines: Evidence from the Multi-Ethnic Study of Atherosclerosis
- Creators
- Anjum Hajat - University of WashingtonAna V Diez Roux - Drexel UniversityCecilia Castro-Diehl - Boston UniversityKristen Cosselman - University of WashingtonSherita Hill Golden - Johns Hopkins UniversityMarnie F Hazlehurst - University of WashingtonAdam Szpiro - University of WashingtonSverre Vedal - University of WashingtonJoel D Kaufman - University of Washington
- Publication Details
- Environmental health perspectives, v 127(5), pp 57007-57007
- Grant note
- K24 ES013195 / NIEHS NIH HHS R21 ES024894 / NIEHS NIH HHS P30 AG028748 / NIA NIH HHS UL1 TR000040 / NCATS NIH HHS R01 HL101161 / NHLBI NIH HHS UL1 TR001079 / NCATS NIH HHS R00 ES023498 / NIEHS NIH HHS P30 ES007033 / NIEHS NIH HHS R01 HL076831 / NHLBI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000471116100003
- Scopus ID
- 2-s2.0-85066878577
- Other Identifier
- 991019168408004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Environmental Sciences
- Public, Environmental & Occupational Health
- Toxicology