Journal article
The Association of Arsenic Exposure and Arsenic Metabolism With the Metabolic Syndrome and Its Individual Components: Prospective Evidence From the Strong Heart Family Study
American journal of epidemiology, v 187(8), pp 1598-1612
01 Aug 2018
PMID: 29554222
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Inorganic arsenic exposure is ubiquitous, and both exposure and interindividual differences in its metabolism have been associated with cardiometabolic risk. However, the associations of arsenic exposure and arsenic metabolism with the metabolic syndrome (MetS) and its individual components are relatively unknown. We used Poisson regression with robust variance to evaluate the associations of baseline arsenic exposure (urinary arsenic levels) and metabolism (relative percentage of arsenic species over their sum) with incident MetS and its individual components (elevated waist circumference, elevated triglycerides, reduced high-density lipoprotein cholesterol, hypertension, and elevated fasting plasma glucose) in 1,047 participants from the Strong Heart Family Study, a prospective family-based cohort study in American Indian communities (baseline visits were held in 1998–1999 and 2001–2003, follow-up visits in 2001–2003 and 2006–2009). Over the course of follow-up, 32% of participants developed MetS. An interquartile-range increase in arsenic exposure was associated with a 1.19-fold (95% confidence interval: 1.01, 1.41) greater risk of elevated fasting plasma glucose concentration but not with other individual components of the MetS or MetS overall. Arsenic metabolism, specifically lower percentage of monomethylarsonic acid and higher percentage of dimethylarsinic acid, was associated with higher risk of overall MetS and elevated waist circumference but not with any other MetS component. These findings support the hypothesis that there are contrasting and independent associations of arsenic exposure and arsenic metabolism with metabolic outcomes which may contribute to overall diabetes risk.
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Details
- Title
- The Association of Arsenic Exposure and Arsenic Metabolism With the Metabolic Syndrome and Its Individual Components: Prospective Evidence From the Strong Heart Family Study
- Creators
- Miranda J Spratlen - Johns Hopkins UniversityMaria Grau-Perez - Universitat de ValènciaLyle G Best - Missouri Breaks Industries Research (United States)Joseph Yracheta - Missouri Breaks Industries Research (United States)Mariana Lazo - Johns Hopkins MedicineDhananjay Vaidya - Johns Hopkins UniversityPoojitha Balakrishnan - Columbia UniversityMary V Gamble - Columbia UniversityKevin A Francesconi - University of GrazWalter Goessler - University of GrazShelley A Cole - Texas Biomedical Research InstituteJason G Umans - MedStar HealthBarbara V Howard - MedStar HealthAna Navas-Acien - Johns Hopkins University
- Publication Details
- American journal of epidemiology, v 187(8), pp 1598-1612
- Publisher
- Oxford University Press
- Grant note
- 1F31ES027796-01; 5T32ES007141-33; R01ES025216; 5P30ES009089; P42ES010349 / ; ; ; R01-HL090863; R01-HL109315; R01HL109301; R01HL109284; R01HL109282; R01HL109319; U01-HL41642; U01-HL41652; U01-HL41654; U01-HL65520; U01-HL65521 / ; ; ;
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000440973400004
- Scopus ID
- 2-s2.0-85047238854
- Other Identifier
- 991020550491404721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health