Journal article
The BestFIT trial: A SMART approach to developing individualized weight loss treatments
Contemporary clinical trials, v 47
Mar 2016
PMID: 26825020
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Behavioral weight loss programs help people achieve clinically meaningful weight losses (8–10% of starting body weight). Despite data showing that only half of participants achieve this goal, a “one size fits all” approach is normative. This weight loss intervention science gap calls for adaptive interventions that provide the “right treatment at the right time for the right person.” Sequential Multiple Assignment Randomized Trials (SMART), use experimental design principles to answer questions for building adaptive interventions including whether, how, or when to alter treatment intensity, type, or delivery. This paper describes the rationale and design of the BestFIT study, a SMART designed to evaluate the optimal timing for intervening with sub-optimal responders to weight loss treatment and relative efficacy of two treatments that address self-regulation challenges which impede weight loss: 1) augmenting treatment with portion-controlled meals (PCM) which decrease the need for self-regulation; and 2) switching to acceptance-based behavior treatment (ABT) which boosts capacity for self-regulation. The primary aim is to evaluate the benefit of changing treatment with PCM versus ABT. The secondary aim is to evaluate the best time to intervene with sub-optimal responders. BestFIT results will lead to the empirically-supported construction of an adaptive intervention that will optimize weight loss outcomes and associated health benefits.
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Details
- Title
- The BestFIT trial: A SMART approach to developing individualized weight loss treatments
- Creators
- Nancy E Sherwood - HealthPartners Institute, 8170 33rd Ave. S., Mail stop 21111R, PO Box 1524, Bloomington, MN 55440-1524, United StatesMeghan L Butryn - Department of Psychology, Drexel University, 3141 Chestnut St Stratton Hall, Philadelphia, PA 19104, United StatesEvan M Forman - Department of Psychology, Drexel University, 3141 Chestnut St Stratton Hall, Philadelphia, PA 19104, United StatesDaniel Almirall - Institute for Social Research, Survey Research Center, University of Michigan, PO Box 1248, 426 Thompson St., Ann Arbor, MI 48106, United StatesElisabeth M Seburg - HealthPartners Institute, 8170 33rd Ave. S., Mail stop 21111R, PO Box 1524, Bloomington, MN 55440-1524, United StatesA Lauren Crain - HealthPartners Institute, 8170 33rd Ave. S., Mail stop 21111R, PO Box 1524, Bloomington, MN 55440-1524, United StatesAlicia S Kunin-Batson - HealthPartners Institute, 8170 33rd Ave. S., Mail stop 21111R, PO Box 1524, Bloomington, MN 55440-1524, United StatesMarcia G Hayes - HealthPartners Institute, 8170 33rd Ave. S., Mail stop 21111R, PO Box 1524, Bloomington, MN 55440-1524, United StatesRona L Levy - School of Social Work, University of Washington, 4101 15th Avenue NE, Seattle, WA 98105-6299, United StatesRobert W Jeffery - Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, West Bank Office Building, 1300 South 2nd St, Suite 300, Minneapolis, MN 55454, United States
- Publication Details
- Contemporary clinical trials, v 47
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Center for Weight, Eating and Lifestyle Science (WELL) [Historical]
- Web of Science ID
- WOS:000374606900028
- Scopus ID
- 2-s2.0-84961327696
- Other Identifier
- 991014877961504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Medicine, Research & Experimental
- Pharmacology & Pharmacy