Journal article
The Bone Microenvironment in Prostate Cancer Metastasis
Advances in experimental medicine and biology, v 1210
2019
PMID: 31900910
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The propensity of prostate cancer cells to seed the skeleton and then progress into clinically relevant metastatic tumors is widely recognized and a major cause of morbidity and mortality for patients. The natural history of prostate adenocarcinoma most frequently begins with a tumor diagnosed at a localized stage, which is successfully treated by surgical and/or radiation therapy modalities. A relevant percentage of patients are clinically cured but approximately 20-30% will develop biochemical signs of recurrence, which respond to the inhibition of androgen receptor (AR) signaling by hormone-deprivation and receptor antagonists, before the inevitable transition into castration-resistant prostate cancer (CRPC). This stage simultaneously presents with or is rapidly followed by secondary tumors, which involve the skeleton in more than 90% of cases (mCRPC). While generalization in clinical practice is always unwise, it is indisputable that bone-metastatic prostate cancer is virtually incurable. Decades of research have revealed that the tissue microenvironment provided by the bone marrow is as important as the cell-autonomous features of tumor cells in fostering the right conditions that lead to establishment and progression of metastatic tumors in the skeleton.
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Details
- Title
- The Bone Microenvironment in Prostate Cancer Metastasis
- Creators
- Anthony DiNatale - Drexel UniversityAlessandro Fatatis - Drexel University
- Publication Details
- Advances in experimental medicine and biology, v 1210
- Publisher
- Springer Nature
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000514081600010
- Scopus ID
- 2-s2.0-85077480168
- Other Identifier
- 303032656X; 9783030326562; 991019168543504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Medicine, Research & Experimental
- Oncology