Journal article
The CHD Protein Kismet Restricts the Synaptic Localization of Cell Adhesion Molecules at the Drosophila Neuromuscular Junction
International journal of molecular sciences, v 25(5), 3074
06 Mar 2024
PMID: 38474321
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The appropriate expression and localization of cell surface cell adhesion molecules must be tightly regulated for optimal synaptic growth and function. How neuronal plasma membrane proteins, including cell adhesion molecules, cycle between early endosomes and the plasma membrane is poorly understood. Here we show that the
homolog of the chromatin remodeling enzymes CHD7 and CHD8, Kismet, represses the synaptic levels of several cell adhesion molecules. Neuroligins 1 and 3 and the integrins αPS2 and βPS are increased at
mutant synapses but Kismet only directly regulates transcription of
. Kismet may therefore regulate synaptic CAMs indirectly by activating transcription of gene products that promote intracellular vesicle trafficking including
(
) and/or
. Knock down of EndoB in all tissues or neurons increases synaptic FasII while knock down of EndoB in
mutants does not produce an additive increase in FasII. In contrast, neuronal expression of Rab11, which is deficient in
mutants, leads to a further increase in synaptic FasII in
mutants. These data support the hypothesis that Kis influences the synaptic localization of FasII by promoting intracellular vesicle trafficking through the early endosome.
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Details
- Title
- The CHD Protein Kismet Restricts the Synaptic Localization of Cell Adhesion Molecules at the Drosophila Neuromuscular Junction
- Creators
- Ireland R Smith - Southern Illinois University EdwardsvilleEmily L Hendricks - Southern Illinois University EdwardsvilleNina K Latcheva - Drexel UniversityDaniel R Marenda - Drexel UniversityFaith L W Liebl (Corresponding Author) - Southern Illinois University Edwardsville
- Publication Details
- International journal of molecular sciences, v 25(5), 3074
- Publisher
- MDPI
- Grant note
- R15 NS101608 / NINDS NIH HHS 1R15NS101608-01A1, 2R15NS101608-02A1 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:001183351200001
- Scopus ID
- 2-s2.0-85187427332
- Other Identifier
- 991022202085204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Multidisciplinary