Journal article
The Categorization of Perinatal Derivatives for Orthopedic Applications
Biomedicines, v 12(7), p1544
11 Jul 2024
PMID: 39062117
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Musculoskeletal (MSK) pathology encompasses an array of conditions that can cause anything from mild discomfort to permanent injury. Their prevalence and impact on disability have sparked interest in more effective treatments, particularly within orthopedics. As a result, the human placenta has come into focus within regenerative medicine as a perinatal derivative (PnD). These biologics are sourced from components of the placenta, each possessing a unique composition of collagens, proteins, and factors believed to aid in healing and regeneration. This review aims to explore the current literature on PnD biologics and their potential benefits for treating various MSK pathologies. We delve into different types of PnDs and their healing effects on muscles, tendons, bones, cartilage, ligaments, and nerves. Our discussions highlight the crucial role of immune modulation in the healing process for each condition. PnDs have been observed to influence the balance between anti- and pro-inflammatory factors and, in some cases, act as biologic scaffolds for tissue growth. Additionally, we assess the range of PnDs available, while also addressing gaps in our understanding, particularly regarding biologic processing methods. Although certain PnD biologics have varying levels of support in orthopedic literature, further clinical investigations are necessary to fully evaluate their impact on human patients.
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Details
- Title
- The Categorization of Perinatal Derivatives for Orthopedic Applications
- Creators
- Amol H. Trivedi - Drexel UniversityVicki Z. Wang - Allegheny General HospitalEdward J. Mcclain - Allegheny General HospitalPraveer S. Vyas - Allegheny Health NetworkIsaac R. Swink - Allegheny Health NetworkEdward D. Snell - Allegheny General HospitalBoyle C. Cheng - Allegheny Health NetworkPatrick J. Demeo - Allegheny General Hospital
- Publication Details
- Biomedicines, v 12(7), p1544
- Publisher
- Mdpi
- Number of pages
- 32
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Surgery
- Web of Science ID
- WOS:001276664600001
- Scopus ID
- 2-s2.0-85199652004
- Other Identifier
- 991021930448104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Medicine, Research & Experimental
- Pharmacology & Pharmacy