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The Chemokine Receptor CXCR3 Promotes CD8 + T Cell Accumulation in Uninfected Salivary Glands but Is Not Necessary after Murine Cytomegalovirus Infection
Journal article   Open access   Peer reviewed

The Chemokine Receptor CXCR3 Promotes CD8 + T Cell Accumulation in Uninfected Salivary Glands but Is Not Necessary after Murine Cytomegalovirus Infection

Sofia Caldeira-Dantas, Thomas Furmanak, Corinne Smith, Michael Quinn, Leyla Y Teos, Adam Ertel, Drishya Kurup, Mayank Tandon, Ilias Alevizos and Christopher M Snyder
The Journal of immunology (1950), v 200(3), pp 1133-1145
01 Feb 2018
DOI: https://doi.org/10.4049/jimmunol.1701272
PMID: 29288198
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.4049/jimmunol.1701272View
Published, Version of Record (VoR)Open Access (License Unspecified),  Open

Abstract

Animals CD8-Positive T-Lymphocytes - immunology Cell Movement - immunology Cells, Cultured Chemokines - metabolism Herpesviridae Infections - immunology Herpesviridae Infections - virology Immunologic Memory - immunology Integrin alpha4 - genetics Interferon-gamma - genetics Mice Mice, Inbred C57BL Mice, Knockout Muromegalovirus - immunology Receptors, CCR5 - genetics Receptors, CXCR3 - genetics Salivary Glands - immunology Salivary Glands - virology
Recent work indicates that salivary glands are able to constitutively recruit CD8 T cells and retain them as tissue-resident memory T cells, independently of local infection, inflammation, or Ag. To understand the mechanisms supporting T cell recruitment to the salivary gland, we compared T cell migration to the salivary gland in mice that were infected or not with murine CMV (MCMV), a herpesvirus that infects the salivary gland and promotes the accumulation of salivary gland tissue-resident memory T cells. We found that acute MCMV infection increased rapid T cell recruitment to the salivary gland but that equal numbers of activated CD8 T cells eventually accumulated in infected and uninfected glands. T cell recruitment to uninfected salivary glands depended on chemokines and the integrin α Several chemokines were expressed in the salivary glands of infected and uninfected mice, and many of these could promote the migration of MCMV-specific T cells in vitro. MCMV infection increased the expression of chemokines that interact with the receptors CXCR3 and CCR5, but neither receptor was needed for T cell recruitment to the salivary gland during MCMV infection. Unexpectedly, however, the chemokine receptor CXCR3 was critical for T cell accumulation in uninfected salivary glands. Together, these data suggest that CXCR3 and the integrin α mediate T cell recruitment to uninfected salivary glands but that redundant mechanisms mediate T cell recruitment after MCMV infection.

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31 citations in Web of Science
29 citations in Scopus

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Immunology
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