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Journal article
The Diabetes Location, Environmental Attributes, and Disparities Network: Protocol for Nested Case Control and Cohort Studies, Rationale, and Baseline Characteristics
JMIR research protocols, v 9(10), pp e21377-e21377
01 Oct 2020
PMID: 33074163
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Diabetes prevalence and incidence vary by neighborhood socioeconomic environment (NSEE) and geographic region in the United States. Identifying modifiable community factors driving type 2 diabetes disparities is essential to inform policy interventions that reduce the risk of type 2 diabetes.
Objective: This paper aims to describe the Diabetes Location, Environmental Attributes, and Disparities (LEAD) Network, a group funded by the Centers for Disease Control and Prevention to apply harmonized epidemiologic approaches across unique and geographically expansive data to identify community factors that contribute to type 2 diabetes risk.
Methods: The Diabetes LEAD Network is a collaboration of 3 study sites and a data coordinating center (Drexel University). The Geisinger and Johns Hopkins University study population includes 578,485 individuals receiving primary care at Geisinger, a health system serving a population representative of 37 counties in Pennsylvania. The New York University School of Medicine study population is a baseline cohort of 6,082,146 veterans who do not have diabetes and are receiving primary care through Veterans Affairs from every US county. The University of Alabama at Birmingham study population includes 11,199 participants who did not have diabetes at baseline from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study, a cohort study with oversampling of participants from the Stroke Belt region.
Results: The Network has established a shared set of aims: evaluate mediation of the association of the NSEE with type 2 diabetes onset, evaluate effect modification of the association of NSEE with type 2 diabetes onset, assess the differential item functioning of community measures by geographic region and community type, and evaluate the impact of the spatial scale used to measure community factors. The Network has developed standardized approaches for measurement.
Conclusions: The Network will provide insight into the community factors driving geographical disparities in type 2 diabetes risk and disseminate findings to stakeholders, providing guidance on policies to ameliorate geographic disparities in type 2 diabetes in the United States.
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Details
- Title
- The Diabetes Location, Environmental Attributes, and Disparities Network: Protocol for Nested Case Control and Cohort Studies, Rationale, and Baseline Characteristics
- Creators
- Annemarie G. Hirsch - GeisingerApril P. Carson - University of Alabama at BirminghamNora L. Lee - Drexel UniversityTara McAlexander - Drexel UniversityCarla Mercado - Centers for Disease Control and PreventionKaren Siegel - Centers for Disease Control and PreventionNyesha C. Black - Noire Analytics, LLCBrian Elbel - New York University Langone Medical CenterD. Leann Long - University of Alabama at BirminghamPriscilla Lopez - New York UniversityLeslie A. McClure - Drexel UniversityMelissa N. Poulsen - GeisingerBrian S. Schwartz - Geisinger Health SystemLorna E. Thorpe - New York University Langone Medical Center
- Publication Details
- JMIR research protocols, v 9(10), pp e21377-e21377
- Publisher
- Jmir Publications, Inc
- Number of pages
- 17
- Grant note
- U01DP006293; U01DP006296; U01DP006299; U01DP006302 / CDC; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA US CDC Division of Diabetes Translation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000582576000034
- Scopus ID
- 2-s2.0-85095756082
- Other Identifier
- 991019168100504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Health Care Sciences & Services
- Public, Environmental & Occupational Health