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Journal article
The Dynamic Associations Between Cortical Thickness and General Intelligence are Genetically Mediated
Cerebral cortex (New York, N.Y. 1991), v 29(11), pp 4743-4752
17 Dec 2019
PMID: 30715232
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The neural substrates of intelligence represent a fundamental but largely uncharted topic in human developmental neuroscience. Prior neuroimaging studies have identified modest but highly dynamic associations between intelligence and cortical thickness (CT) in childhood and adolescence. In a separate thread of research, quantitative genetic studies have repeatedly demonstrated that most measures of intelligence are highly heritable, as are many brain regions associated with intelligence. In the current study, we integrate these 2 streams of prior work by examining the genetic contributions to CT-intelligence relationships using a genetically informative longitudinal sample of 813 typically developing youth, imaged with high-resolution MRI and assessed with Wechsler Intelligence Scales (IQ). In addition to replicating the phenotypic association between multimodal association cortex and language centers with IQ, we find that CT-IQ covariance is nearly entirely genetically mediated. Moreover, shared genetic factors drive the rapidly evolving landscape of CT-IQ relationships in the developing brain.
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Details
- Title
- The Dynamic Associations Between Cortical Thickness and General Intelligence are Genetically Mediated
- Creators
- J Eric Schmitt - Hospital of the University of PennsylvaniaArmin Raznahan - National Institute of Mental HealthLiv S Clasen - National Institute of Mental HealthGreg L Wallace - George Washington UniversityJoshua N Pritikin - Virginia Commonwealth UniversityNancy Raitano Lee - Drexel UniversityJay N Giedd - University of California, San DiegoMichael C Neale - Virginia Commonwealth University
- Publication Details
- Cerebral cortex (New York, N.Y. 1991), v 29(11), pp 4743-4752
- Publisher
- Oxford University Press
- Grant note
- T32 MH020030 / NIMH NIH HHS K01 ES026840 / NIEHS NIH HHS ZIA MH002949-01 / NIMH NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000506813700020
- Scopus ID
- 2-s2.0-85075462723
- Other Identifier
- 991019167873304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences