Journal article
The Ebola Virus Glycoprotein and HIV-1 Vpu Employ Different Strategies to Counteract the Antiviral Factor Tetherin
The Journal of infectious diseases, v 204(Suppl 3), pp S850-S860
01 Nov 2011
PMID: 21987761
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The antiviral protein tetherin/BST2/CD317/HM1.24 restricts cellular egress of human immunodeficiency virus (HIV) and of particles mimicking the Ebola virus (EBOV), a hemorrhagic fever virus. The HIV-1 viral protein U (Vpu) and the EBOV-glycoprotein (EBOV-GP) both inhibit tetherin. Here, we compared tetherin counteraction by EBOV-GP and Vpu. We found that EBOV-GP but not Vpu counteracted tetherin from different primate species, indicating that EBOV-GP and Vpu target tetherin differentially. Tetherin interacted with the GP2 subunit of EBOV-GP, which might encode the determinants for tetherin counteraction. Vpu reduced cell surface expression of tetherin while EBOV-GP did not, suggesting that both proteins employ different mechanisms to counteract tetherin. Finally, Marburg virus (MARV)–GP also inhibited tetherin and downregulated tetherin in a cell type–dependent fashion, indicating that tetherin antagonism depends on the cellular source of tetherin. Collectively, our results indicate that EBOV-GP counteracts tetherin by a novel mechanism and that tetherin inhibition is conserved between EBOV-GP and MARV-GP.
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Details
- Title
- The Ebola Virus Glycoprotein and HIV-1 Vpu Employ Different Strategies to Counteract the Antiviral Factor Tetherin
- Creators
- Annika Kühl - Hannover Medical SchoolCarina Banning - Institute of Virology, Hannover Medical School Heinrich Pette Institute – Leibniz Institute for Experimental Virology and Immunology, Hamburg, Germany Laboratory of Virology, Division of Intramural Research, NIAID, NIH, Rocky Mountain Laboratories, Hamilton, Montana Institute of Virology Department of Surgery, Division of Molecular and Experimental Surgery, University of Erlangen Nuremberg, Germany Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania Clinic for Immunology and Rheumatology, Hannover Medical School Department of Infection Biology, German Primate Research Center, Göttingen, GermanyAndrea Marzi - Institute of Virology, Hannover Medical School Heinrich Pette Institute – Leibniz Institute for Experimental Virology and Immunology, Hamburg, Germany Laboratory of Virology, Division of Intramural Research, NIAID, NIH, Rocky Mountain Laboratories, Hamilton, Montana Institute of Virology Department of Surgery, Division of Molecular and Experimental Surgery, University of Erlangen Nuremberg, Germany Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania Clinic for Immunology and Rheumatology, Hannover Medical School Department of Infection Biology, German Primate Research Center, Göttingen, GermanyJörg Votteler - Institute of Virology, Hannover Medical School Heinrich Pette Institute – Leibniz Institute for Experimental Virology and Immunology, Hamburg, Germany Laboratory of Virology, Division of Intramural Research, NIAID, NIH, Rocky Mountain Laboratories, Hamilton, Montana Institute of Virology Department of Surgery, Division of Molecular and Experimental Surgery, University of Erlangen Nuremberg, Germany Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania Clinic for Immunology and Rheumatology, Hannover Medical School Department of Infection Biology, German Primate Research Center, Göttingen, GermanyImke Steffen - Institute of Virology, Hannover Medical School Heinrich Pette Institute – Leibniz Institute for Experimental Virology and Immunology, Hamburg, Germany Laboratory of Virology, Division of Intramural Research, NIAID, NIH, Rocky Mountain Laboratories, Hamilton, Montana Institute of Virology Department of Surgery, Division of Molecular and Experimental Surgery, University of Erlangen Nuremberg, Germany Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania Clinic for Immunology and Rheumatology, Hannover Medical School Department of Infection Biology, German Primate Research Center, Göttingen, GermanyStephanie Bertram - Institute of Virology, Hannover Medical School Heinrich Pette Institute – Leibniz Institute for Experimental Virology and Immunology, Hamburg, Germany Laboratory of Virology, Division of Intramural Research, NIAID, NIH, Rocky Mountain Laboratories, Hamilton, Montana Institute of Virology Department of Surgery, Division of Molecular and Experimental Surgery, University of Erlangen Nuremberg, Germany Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania Clinic for Immunology and Rheumatology, Hannover Medical School Department of Infection Biology, German Primate Research Center, Göttingen, GermanyIlona Glowacka - Institute of Virology, Hannover Medical School Heinrich Pette Institute – Leibniz Institute for Experimental Virology and Immunology, Hamburg, Germany Laboratory of Virology, Division of Intramural Research, NIAID, NIH, Rocky Mountain Laboratories, Hamilton, Montana Institute of Virology Department of Surgery, Division of Molecular and Experimental Surgery, University of Erlangen Nuremberg, Germany Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania Clinic for Immunology and Rheumatology, Hannover Medical School Department of Infection Biology, German Primate Research Center, Göttingen, GermanyAndreas Konrad - Institute of Virology, Hannover Medical School Heinrich Pette Institute – Leibniz Institute for Experimental Virology and Immunology, Hamburg, Germany Laboratory of Virology, Division of Intramural Research, NIAID, NIH, Rocky Mountain Laboratories, Hamilton, Montana Institute of Virology Department of Surgery, Division of Molecular and Experimental Surgery, University of Erlangen Nuremberg, Germany Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania Clinic for Immunology and Rheumatology, Hannover Medical School Department of Infection Biology, German Primate Research Center, Göttingen, GermanyMichael Stürzl - Institute of Virology, Hannover Medical School Heinrich Pette Institute – Leibniz Institute for Experimental Virology and Immunology, Hamburg, Germany Laboratory of Virology, Division of Intramural Research, NIAID, NIH, Rocky Mountain Laboratories, Hamilton, Montana Institute of Virology Department of Surgery, Division of Molecular and Experimental Surgery, University of Erlangen Nuremberg, Germany Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania Clinic for Immunology and Rheumatology, Hannover Medical School Department of Infection Biology, German Primate Research Center, Göttingen, GermanyJu-Tao Guo - Drexel UniversityUlrich Schubert - Institute of Virology, Hannover Medical School Heinrich Pette Institute – Leibniz Institute for Experimental Virology and Immunology, Hamburg, Germany Laboratory of Virology, Division of Intramural Research, NIAID, NIH, Rocky Mountain Laboratories, Hamilton, Montana Institute of Virology Department of Surgery, Division of Molecular and Experimental Surgery, University of Erlangen Nuremberg, Germany Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania Clinic for Immunology and Rheumatology, Hannover Medical School Department of Infection Biology, German Primate Research Center, Göttingen, GermanyHeinz Feldmann - Institute of Virology, Hannover Medical School Heinrich Pette Institute – Leibniz Institute for Experimental Virology and Immunology, Hamburg, Germany Laboratory of Virology, Division of Intramural Research, NIAID, NIH, Rocky Mountain Laboratories, Hamilton, Montana Institute of Virology Department of Surgery, Division of Molecular and Experimental Surgery, University of Erlangen Nuremberg, Germany Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania Clinic for Immunology and Rheumatology, Hannover Medical School Department of Infection Biology, German Primate Research Center, Göttingen, GermanyGeorg Behrens - Institute of Virology, Hannover Medical School Heinrich Pette Institute – Leibniz Institute for Experimental Virology and Immunology, Hamburg, Germany Laboratory of Virology, Division of Intramural Research, NIAID, NIH, Rocky Mountain Laboratories, Hamilton, Montana Institute of Virology Department of Surgery, Division of Molecular and Experimental Surgery, University of Erlangen Nuremberg, Germany Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania Clinic for Immunology and Rheumatology, Hannover Medical School Department of Infection Biology, German Primate Research Center, Göttingen, GermanyMichael Schindler - Institute of Virology, Hannover Medical School Heinrich Pette Institute – Leibniz Institute for Experimental Virology and Immunology, Hamburg, Germany Laboratory of Virology, Division of Intramural Research, NIAID, NIH, Rocky Mountain Laboratories, Hamilton, Montana Institute of Virology Department of Surgery, Division of Molecular and Experimental Surgery, University of Erlangen Nuremberg, Germany Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania Clinic for Immunology and Rheumatology, Hannover Medical School Department of Infection Biology, German Primate Research Center, Göttingen, GermanyStefan Pöhlmann - Institute of Virology, Hannover Medical School Heinrich Pette Institute – Leibniz Institute for Experimental Virology and Immunology, Hamburg, Germany Laboratory of Virology, Division of Intramural Research, NIAID, NIH, Rocky Mountain Laboratories, Hamilton, Montana Institute of Virology Department of Surgery, Division of Molecular and Experimental Surgery, University of Erlangen Nuremberg, Germany Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania Clinic for Immunology and Rheumatology, Hannover Medical School Department of Infection Biology, German Primate Research Center, Göttingen, Germany
- Publication Details
- The Journal of infectious diseases, v 204(Suppl 3), pp S850-S860
- Publisher
- Oxford University Press
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000295991400015
- Scopus ID
- 2-s2.0-80054725684
- Other Identifier
- 991019168480004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Immunology
- Infectious Diseases
- Microbiology