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Journal article
The Effect of Mitochondrial Supplements on Mitochondrial Activity in Children with Autism Spectrum Disorder
Journal of clinical medicine, v 6(2)
01 Feb 2017
PMID: 28208802
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Treatment for mitochondrial dysfunction is typically guided by expert opinion with a paucity of empirical evidence of the effect of treatment on mitochondrial activity. We examined citrate synthase and Complex I and IV activities using a validated buccal swab method in 127 children with autism spectrum disorder with and without mitochondrial disease, a portion of which were on common mitochondrial supplements. Mixed-model linear regression determined whether specific supplements altered the absolute mitochondrial activity as well as the relationship between the activities of mitochondrial components. Complex I activity was increased by fatty acid and folate supplementation, but folate only effected those with mitochondrial disease. Citrate synthase activity was increased by antioxidant supplementation but only for the mitochondrial disease subgroup. The relationship between Complex I and IV was modulated by folate while the relationship between Complex I and Citrate Synthase was modulated by both folate and B12. This study provides empirical support for common mitochondrial treatments and demonstrates that the relationship between activities of mitochondrial components might be a marker to follow in addition to absolute activities. Measurements of mitochondrial activity that can be practically repeated over time may be very useful to monitor the biochemical effects of treatments.
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Details
- Title
- The Effect of Mitochondrial Supplements on Mitochondrial Activity in Children with Autism Spectrum Disorder
- Creators
- Leanna M. Delhey - University of Arkansas for Medical SciencesEkim Nur Kilinc - Arkansas Children's HospitalLi Yin - West China Hospital of Sichuan UniversityJohn C. Slattery - University of Arkansas for Medical SciencesMarie L. Tippett - University of Arkansas for Medical SciencesShannon Rose - University of Arkansas for Medical SciencesSirish C. Bennuri - University of Arkansas for Medical SciencesStephen G. Kahler - University of Arkansas for Medical SciencesShirish Damle - Drexel UniversityAgustin Legido - Department of Pediatrics, Drexel University College of Medicine, Neurology Section, St. Christopher's Hospital for Children, Philadelphia, PA 19134, USA. agustin.legido@drexelmed.edu.Michael J. Goldenthal - Drexel UniversityRichard E. Frye - University of Arkansas for Medical Sciences
- Publication Details
- Journal of clinical medicine, v 6(2)
- Publisher
- Mdpi
- Number of pages
- 12
- Grant note
- Arkansas Biosciences Institute (Little Rock, AR, USA) Gupta family Autism Research Institute (San Diego, CA, USA) Arkansas Children's Research Institute (Little Rock, AR, USA) Jane Botsford Johnson Foundation (New York, NY, USA)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics; School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000397271200006
- Scopus ID
- 2-s2.0-85114281741
- Other Identifier
- 991019168837904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Pediatrics