Logo image
Back
The Effects of the Menstrual Cycle on the Incidence of Emesis and Efficacy of Ondansetron
Journal article   Open access   Peer reviewed

The Effects of the Menstrual Cycle on the Incidence of Emesis and Efficacy of Ondansetron

Irwin Gratz, Elaine Allen, Mary Afshar, Alan F Joslyn, Jodie Buxbaum, Barbara Prilliman and Erika M Allen
Anesthesia and analgesia, v 83(3), pp 565-569
Sep 1996
DOI: https://doi.org/10.1097/00000539-199609000-00022
PMID: 8780282
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1097/00000539-199609000-00022View
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze),  Open

Abstract

Postoperative nausea and vomiting after general anesthesia remains a complex and perturbing phenomenon associated with several factors.In women, the phase of the menstrual cycle as a factor in postoperative nausea and emesis is controversial. This retrospective study was performed to assess the effects of the menstrual cycle and efficacy of the antiemetic ondansetron on postoperative emesis. A total of 1169 ASA grade I-II patients from two double-blind, placebo-controlled studies were enrolled in 18 centers. Patients with irregular cycles or taking estrogens or progesterones were excluded from the analysis, leaving 873 patients eligible for this study. The patients were stratified on the basis of their last menses into four groups1) 1-8, 2) 9-16, 3) 17-28, and 4) 29-35 days. All patients received a general anesthetic with endotracheal intubation. Patients received either 1, 4, or 8 mg ondansetron or placebo given intravenously before induction of anesthesia. All patients were studied for a 24-h period. Emesis rates were compared with respect to the phase of the menstrual cycle and between menstruating and nonmenstruating patients. There was no relationship (P = 0.100) between the incidence of emesis and the phase of the menstrual cycle in the group receiving the placebo. There was, however, a significant reduction (P < 0.001) in emesis for the ondansetron-treated patients regardless of the phase of the menstrual cycle. In addition, ondansetron had a similar dose-response curve in both menstruating and nonmenstruating women.(Anesth Analg 1996;83:565-9)

Metrics

9 Record Views
28 citations in Web of Science
40 citations in Scopus

Details

UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

InCites Highlights

Data related to this publication, from InCites Benchmarking & Analytics tool:

Collaboration types
Industry collaboration
Domestic collaboration
Web of Science research areas
Anesthesiology
Logo image