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Journal article
The Elegance of Sonic Hedgehog: Emerging Novel Functions for a Classic Morphogen
The Journal of neuroscience, v 38(44), pp 9338-9345
31 Oct 2018
PMID: 30381425
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Sonic Hedgehog (SHH) signaling has been most widely known for its role in specifying region and cell-type identity during embryonic morphogenesis. This mini-review accompanies a 2018 SFN mini-symposium that addresses an emerging body of research focused on understanding the diverse roles for Shh signaling in a wide range of contexts in neurodevelopment and, more recently, in the mature CNS. Such research shows that Shh affects the function of brain circuits, including the production and maintenance of diverse cell types and the establishment of wiring specificity. Here, we review these novel and unexpected functions and the unanswered questions regarding the role of SHH and its signaling pathway members in these cases.
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Details
- Title
- The Elegance of Sonic Hedgehog: Emerging Novel Functions for a Classic Morphogen
- Creators
- A Denise R Garcia - Drexel UniversityYoung-Goo Han - St. Jude Children's Research HospitalJason W Triplett - George Washington UniversityW Todd Farmer - Montreal General HospitalCorey C Harwell - Harvard UniversityRebecca A Ihrie - Vanderbilt University
- Publication Details
- The Journal of neuroscience, v 38(44), pp 9338-9345
- Publisher
- Society for Neuroscience
- Grant note
- R01 NS100939 / NINDS NIH HHS P30 CA068485 / NCI NIH HHS R21 MH110724 / NIMH NIH HHS R01 EY025627 / NEI NIH HHS R13 NS098720 / NINDS NIH HHS F32 NS010228 / NINDS NIH HHS R01 NS096100 / NINDS NIH HHS K01 MH097957 / NIMH NIH HHS U54 HD090257 / NICHD NIH HHS R01 NS096238 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000448791600004
- Scopus ID
- 2-s2.0-85055844251
- Other Identifier
- 991019168136604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences