Journal article
The Epidemiology of Autism Spectrum Disorders
Annual review of public health, v 28(1), pp 235-258
01 Apr 2007
PMID: 17367287
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Autism spectrum disorders (ASDs) are complex, lifelong, neurodevelopmental conditions of largely unknown cause. They are much more common than previously believed, second in frequency only to mental retardation among the serious developmental disorders. Although a heritable component has been demonstrated in ASD etiology, putative risk genes have yet to be identified. Environmental risk factors may also play a role, perhaps via complex gene-environment interactions, but no specific exposures with significant population effects are known. A number of endogenous biomarkers associated with autism risk have been investigated, and these may help identify significant biologic pathways that, in turn, will aid in the discovery of specific genes and exposures. Future epidemiologic research should focus on expanding population-based descriptive data on ASDs, exploring candidate risk factors in large well-designed studies incorporating both genetic and environmental exposure data and addressing possible etiologic heterogeneity in studies that can stratify case groups and consider alternate endophenotypes.
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Details
- Title
- The Epidemiology of Autism Spectrum Disorders
- Creators
- Craig J. Newschaffer - Drexel UniversityLisa A. Croen - Kaiser PermanenteJulie Daniels - University of North Carolina at Chapel HillEllen Giarelli - University of PennsylvaniaJudith K. Grether - California Health and Human Services AgencySusan E. Levy - Department of PediatricsDavid S. Mandell - University of PennsylvaniaLisa A. Miller - Colorado Department of Public Health and EnvironmentJennifer Pinto-Martin - University of PennsylvaniaJudy Reaven - University of Colorado Anschutz Medical CampusAnn M. Reynolds - University of DenverCatherine E. Rice - Centers for Disease Control and PreventionDiana Schendel - Centers for Disease Control and PreventionGayle C. Windham - California Health and Human Services Agency
- Publication Details
- Annual review of public health, v 28(1), pp 235-258
- Publisher
- Annual Reviews
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]; A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000246436700015
- Scopus ID
- 2-s2.0-34249735268
- Other Identifier
- 991019168553304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health